Liang Jinhui, Gao Shan, Zhang Jian, Ao Hongmin, Wei Xianlin, Luo Hailin
Department of Otolaryngology, Central Hospital of Hanzhong, Hanzhong, 723000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Oct;23(20):933-5.
To investigate the expression of Survivin and its relationship with the expression of Bcl-2 in sinonasal inverted papilloma (SNIP).
Immunohistochemical method was used to determine the expression of Survivin and Bcl-2 in 30 cases of SNIP, 10 cases of sinonasal squamous cell carcinoma (SCC) and 10 cases of normal inferior concha tissues.
Survivin was expressed in 22 of 30 (73.3%) cases of SNIP, 8 of 10 (80.0%) cases of SCC and not expressed in 10 (0%) cases of normal inferior concha tissues. Expression of Survivin was significantly higher in SNIP and SCC than in normal tissues. Bcl-2 was expressed in 9 of 10 (90.0%) cases of SCC and 2 of 10 (20.0%) cases of normal inferior concha tissues. Expression of Bcl-2 was significantly higher in SCC than in normal tissues. Bcl-2 was expressed in 14 of 30 (46.7%) cases of SNIP, higher than normal tissues. Expression of Bcl-2 was positively related to expression of Survivin.
Survivin may play an important role in the pathway of progression of SNIP and SCC. It may be identified as a new therapeutic target. Bcl-2 may play a synergic role with Survivin in progression of SNIP.
探讨生存素（Survivin）在鼻腔鼻窦内翻性乳头状瘤（SNIP）中的表达及其与Bcl-2表达的关系。
采用免疫组织化学方法检测30例SNIP、10例鼻腔鼻窦鳞状细胞癌（SCC）及10例正常下鼻甲组织中Survivin和Bcl-2的表达。
Survivin在30例SNIP中的22例（73.3%）、10例SCC中的8例（80.0%）有表达，在10例正常下鼻甲组织中均无表达（0%）。Survivin在SNIP和SCC中的表达显著高于正常组织。Bcl-2在10例SCC中的9例（90.0%）及10例正常下鼻甲组织中的2例（20.0%）有表达。Bcl-2在SCC中的表达显著高于正常组织。Bcl-2在30例SNIP中的14例（46.7%）有表达，高于正常组织。Bcl-2的表达与Survivin的表达呈正相关。
Survivin可能在SNIP和SCC的进展途径中起重要作用，有望成为新的治疗靶点。Bcl-2可能在SNIP进展过程中与Survivin发挥协同作用。
