解读蛋白质序列中的信息：对氨基酸替换的耐受性
Deciphering the message in protein sequences: tolerance to amino acid substitutions.
作者信息
Bowie J U, Reidhaar-Olson J F, Lim W A, Sauer R T
机构信息
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Science. 1990 Mar 16;247(4948):1306-10. doi: 10.1126/science.2315699.
PMID:2315699
Abstract
An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.
摘要
氨基酸序列编码一种信息，该信息决定了蛋白质的形状和功能。这种信息具有高度简并性，因为许多不同的序列可以编码具有基本相同结构和活性的蛋白质。比较具有相似信息的不同序列可以揭示编码的关键特征，并增进对蛋白质如何折叠以及如何发挥其功能的理解。
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