Kocher Charles, Dill Ken A
Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, USA.
Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY, USA.
QRB Discov. 2023 Mar 22;4:e4. doi: 10.1017/qrd.2023.2. eCollection 2023.
When life arose from prebiotic molecules 3.5 billion years ago, what came first? Informational molecules (RNA, DNA), functional ones (proteins), or something else? We argue here for a different logic: rather than seeking a , we seek a Biology required an ability to evolve before it could choose and optimise materials. We hypothesise that the was rooted in the Modelling shows how short random peptides can collapse in water and catalyse the elongation of others, powering both increased folding stability and emergent autocatalysis through a disorder-to-order process.
35亿年前，当生命从益生元分子中诞生时，什么是最先出现的？是信息分子（RNA、DNA）、功能分子（蛋白质），还是其他什么？我们在此提出一种不同的逻辑：与其寻找一个[此处原文缺失内容]，我们寻找的是一个[此处原文缺失内容]。生物学在能够选择和优化物质之前，需要具备进化的能力。我们假设[此处原文缺失内容]根植于[此处原文缺失内容]。模型显示，短随机肽如何在水中折叠并催化其他肽的延伸，通过一个从无序到有序的过程，增强折叠稳定性并引发自催化作用。
