Zhuang Xi-bin, Huang Hong-bo, Chen Wei-wen, Huang Hong, Guo Wei-feng
Department of Respiratory, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou 362000, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2012 Aug;35(8):606-9.
To investigate the relationship between serum Substance P levels and excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).
A total of 120 adult habitual snorers treated by respiratory physicians in First Hospital of Quanzhou Affiliated to Fujian Medical University were selected for this study. The patients were grouped as simple snorers and OSAHS by the results of polysomnography test. Thirty patients were in the simple snorer group, among whom 24 were male and 6 were female. Their average age was (48 ± 15) years and average AHI was (2.8 ± 1.6) events/hour. Ninety patients were in the OSAHS group, among whom 78 were male and 12 were female. Their average age was (49 ± 12) years and average AHI was (37.1 ± 23.7) events/hour. EDS was assessed using the Epworth sleepiness scale (ESS). Substance P levels were analyzed with a radioimmunoassay.
There was no significant difference in gender, age, and body mass index between the 2 groups. The ESS score for patients with OSAHS was (13 ± 5), higher than that for patients in the simple snorer group (F = 10.299, P < 0.05). With increasing severity of OSAHS, the score increased. The serum Substance P level for OSAHS group was (132 ± 27) ng/L, which was lower than that in the control (F = 3.048, P = 0.031), and decrease in Substance P level was most significant in patients with severe OSAHS. Pearson correlation analysis showed that Substance P levels in OSAHS patients were negatively correlated with ESS scores (r = -0.238, P < 0.05).
Substance P levels were lower in OSAHS patients with higher degree of daytime sleepiness. Daytime sleepiness and Substance P level were interrelated in patients with OSAHS.
探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血清P物质水平与日间过度嗜睡（EDS）之间的关系。
选取福建医科大学附属泉州第一医院呼吸内科收治的120例成年习惯性打鼾者作为研究对象。根据多导睡眠图测试结果将患者分为单纯打鼾组和OSAHS组。单纯打鼾组30例，其中男性24例，女性6例，平均年龄（48±15）岁，平均呼吸暂停低通气指数（AHI）为（2.8±1.6）次/小时。OSAHS组90例，其中男性78例，女性12例，平均年龄（49±12）岁，平均AHI为（37.1±23.7）次/小时。采用Epworth嗜睡量表（ESS）评估EDS。采用放射免疫分析法分析P物质水平。
两组患者在性别、年龄和体重指数方面无显著差异。OSAHS患者的ESS评分为（13±5），高于单纯打鼾组患者（F=10.299，P<0.05）。随着OSAHS严重程度的增加，评分升高。OSAHS组血清P物质水平为（132±27）ng/L，低于对照组（F=3.048，P=0.031），且P物质水平下降在重度OSAHS患者中最为显著。Pearson相关性分析显示，OSAHS患者的P物质水平与ESS评分呈负相关（r=-0.238，P<0.05）。
日间嗜睡程度较高的OSAHS患者P物质水平较低。OSAHS患者的日间嗜睡与P物质水平相关。
