Department of Orthodontics, Peking University School of Stomatology, Beijing, China.
Chin Med J (Engl). 2012 Nov;125(22):4018-21.
Enamel decalcification in orthodontics is a concern for dentists and methods to remineralize these lesions are the focus of intense research. The aim of this study was to evaluate the remineralizing effect of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) nanocomplexes on enamel decalcification in orthodontics.
Twenty orthodontic patients with decalcified enamel lesions during fixed orthodontic therapy were recruited to this study as test group and twenty orthodontic patients with the similar condition as control group. GC Tooth Mousse, the main component of which is CPP-ACP, was used by each patient of test group every night after tooth-brushing for six months. For control group, each patient was asked to brush teeth with toothpaste containing 1100 parts per million (ppm) of fluoride twice a day. Standardized intraoral images were taken for all patients and the extent of enamel decalcification was evaluated before and after treatment over this study period. Measurements were statistically compared by t test.
After using CPP-ACP for six months, the enamel decalcification index (EDI) of all patients had decreased; the mean EDI before using CPP-ACP was 0.191 ± 0.025 and that after using CPP-ACP was 0.183 ± 0.023, the difference was significant (t = 5.169, P < 0.01). For control group, the mean EDI before treatment was 0.188 ± 0.037 and that after treatment was 0.187 ± 0.046, the difference was not significant (t = 1.711, P > 0.05).
CPP-ACP can effectively improve the demineralized enamel lesions during orthodontic treatment, so it has some remineralization potential for enamel decalcification in orthodontics.
正畸过程中釉质脱矿是牙医关注的问题，寻找能够再矿化这些病变的方法是研究的重点。本研究旨在评估酪蛋白磷酸肽-无定形磷酸钙纳米复合物（CPP-ACP）对正畸釉质脱矿的再矿化效果。
本研究纳入 20 名在固定正畸治疗过程中出现釉质脱矿的正畸患者作为实验组，另选 20 名具有相似情况的正畸患者作为对照组。实验组患者每晚刷牙后使用含 CPP-ACP 的 GC Tooth Mousse，对照组患者每天使用含 1100ppm 氟化物的牙膏刷牙两次。在整个研究期间，对所有患者进行标准化的口腔内图像采集，并在治疗前后评估釉质脱矿的程度。采用 t 检验对测量结果进行统计学比较。
使用 CPP-ACP 六个月后，所有患者的釉质脱矿指数（EDI）均降低；使用 CPP-ACP 前的平均 EDI 为 0.191 ± 0.025，使用 CPP-ACP 后的平均 EDI 为 0.183 ± 0.023，差异有统计学意义（t = 5.169，P < 0.01）。对照组治疗前的平均 EDI 为 0.188 ± 0.037，治疗后的平均 EDI 为 0.187 ± 0.046，差异无统计学意义（t = 1.711，P > 0.05）。
CPP-ACP 能有效改善正畸治疗过程中的脱矿釉质病变，因此对正畸釉质脱矿具有一定的再矿化潜力。
