Limeback Hardy, Enax Joachim, Meyer Frederic
Faculty of Dentistry, University of Toronto, Toronto, ON M5G 1G6, Canada.
Dr. Kurt Wolff GmbH & Co. KG, Research Department, Johanneswerkstr. 34-36, 33611 Bielefeld, Germany.
Biomimetics (Basel). 2023 Jul 27;8(4):331. doi: 10.3390/biomimetics8040331.
As the demand for clinically effective fluoride-free oral care products for consumers increases, it is important to document which types of toothpastes have been shown in clinical studies to be effective in improving oral health. In this review, we included different indications, i.e., caries prevention, improving periodontal health, reducing dentin hypersensitivity, protecting against dental erosion, and safely improving tooth whitening in defining what constitutes improvement in oral health. While there are several professional and consumer fluoride-containing formulations fortified with calcium-phosphate-based ingredients, this review focuses on fluoride-free toothpastes containing biomimetic calcium-phosphate-based molecules as the primary active ingredients. Several databases were searched, and only clinical trials in human subjects were included; in vitro and animal studies were excluded. There were 62 oral health clinical trials on biomimetic hydroxyapatite (HAP), 57 on casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), 26 on calcium sodium phosphosilicate (CSPS, or so called Bioglass), and 2 on β-tricalcium phosphate (β-TCP). HAP formulations were tested the most in clinical trials for benefits in preventing caries, dentin hypersensitivity, improving periodontal health, and tooth whitening. Based on the current clinical evidence to date, fluoride-free HAP toothpaste formulations are the most versatile of the calcium phosphate active ingredients in toothpastes for improving oral health.
随着消费者对临床有效的无氟口腔护理产品的需求增加，记录哪些类型的牙膏在临床研究中已被证明对改善口腔健康有效变得很重要。在本综述中，我们纳入了不同的指标，即预防龋齿、改善牙周健康、减轻牙本质过敏、预防牙齿侵蚀以及安全地改善牙齿美白，以此来定义口腔健康改善的构成要素。虽然有几种专业和消费者含氟配方添加了磷酸钙基成分，但本综述重点关注以仿生磷酸钙基分子作为主要活性成分的无氟牙膏。我们检索了几个数据库，仅纳入了针对人类受试者的临床试验；体外和动物研究被排除在外。有62项关于仿生羟基磷灰石（HAP）的口腔健康临床试验，57项关于酪蛋白磷酸肽 - 无定形磷酸钙（CPP - ACP）的试验，26项关于磷酸硅钙钠（CSPS，即所谓的生物活性玻璃）的试验，以及2项关于β - 磷酸三钙（β - TCP）的试验。HAP配方在预防龋齿、牙本质过敏、改善牙周健康和牙齿美白方面的临床试验中测试最多。基于目前的临床证据，无氟HAP牙膏配方是牙膏中用于改善口腔健康的磷酸钙活性成分中用途最广泛的。
