Rajendran Ratheesh, Hussain M Sadique, Sandhya Raghu, Ashik Mohammed, Thomas Arun Jacob, Mammen Reni Elizabeth
Department of Conservative Dentistry and Endodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India.
Department of Oral and Maxillofacial Surgery, Noorul Islam College of Dental Science, Thiruvananthapuram, Kerala, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S7-S12. doi: 10.4103/jpbs.jpbs_836_21. Epub 2022 Jul 13.
The goal of this systematic review was to evaluate the therapeutic efficacy of Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP) remineralizing potential to that of other remineralizing treatments and placebo in both naturally occurring and postorthodontic white spot lesions (WSL) .
From 2005 to 2020, the literature search used electronic databases PubMed, Embase, Science Direct, and Google Scholar to find studies published solely in English and randomized controlled trials (RCTs) employing CPP-ACP as an intervention. All eligible studies were reviewed by two independent reviewers.
Excluding duplications, 72 articles were identified. Abstracts of 58 articles were reviewed independently, 19 articles were excluded, 36 full text articles were retrieved; finally selecting 14 studies.
The CPP-ACP was found to have efficacious remineralizing potential on naturally occurring and postorthodontic WSL compared to placebo or other preventive measures. Further well-performed RCTs are needed to determine the therapeutic significance of remineralizing medicines, and long-term follow-ups are required.
本系统评价的目的是评估酪蛋白磷酸肽无定形磷酸钙（CPP-ACP）与其他再矿化治疗方法及安慰剂相比，对自然发生的和正畸后白斑病变（WSL）的再矿化潜力的治疗效果。
2005年至2020年，文献检索使用电子数据库PubMed、Embase、Science Direct和谷歌学术，以查找仅以英文发表的研究以及采用CPP-ACP作为干预措施的随机对照试验（RCT）。所有符合条件的研究均由两名独立评审员进行审查。
排除重复项后，共识别出72篇文章。独立审查了58篇文章的摘要，排除了19篇文章，检索到36篇全文文章；最终选择了14项研究。
与安慰剂或其他预防措施相比，发现CPP-ACP对自然发生的和正畸后的WSL具有有效的再矿化潜力。需要进一步开展实施良好的随机对照试验来确定再矿化药物的治疗意义，并且需要进行长期随访。
