Perry Lynn P, Jakobiec Frederick A, Zakka Fouad R, Walton David S
David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
J AAPOS. 2012 Dec;16(6):565-8. doi: 10.1016/j.jaapos.2012.06.012. Epub 2012 Nov 14.
We present histopathologic findings that have not been previously reported as associated with abnormalities of the anterior chamber angle underlying newborn primary congenital glaucoma as a distinct entity. The major histopathologic findings were partial absence and retrodisplacement of Schlemm's canal, hypoplasia of the trabecular meshwork, broad attachment of ciliary muscle to the meshwork, and anterior insertion of hypoplastic iris with the formation of a pseudomembrane. These profound anatomic derangements explain why goniosurgery is frequently unsuccessful in cases of newborn glaucoma.
我们展示了一些组织病理学发现，这些发现以前未被报道与新生儿原发性先天性青光眼作为一种独特实体的前房角异常相关。主要组织病理学发现包括施莱姆管部分缺失和向后移位、小梁网发育不全、睫状肌与小梁网广泛附着以及发育不全的虹膜向前插入并形成假膜。这些严重的解剖学紊乱解释了为什么在新生儿青光眼病例中，前房角手术常常不成功。
