Abougalambou Salwa Selim Ibrahim, Abougalambou Ayman Selim
Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Malaysia.
Diabetes Metab Syndr. 2012 Jul-Sep;6(3):167-72. doi: 10.1016/j.dsx.2012.09.002. Epub 2012 Oct 26.
The aim of this study was to determine risk factors and prevalence of diabetic neuropathy (DN) among type II diabetic patients in Malaysian hospital setting.
a observational prospective longitudinal follow up study design was selected, total no of respondents were 1077 type 2 diabetes mellitus outpatients recruited via attended the diabetes clinics at Hospital Universiti Sains Malaysia (HUSM) in Kelantan. The diagnosis of neuropathy was confirmed by nerve conduction studies. Logistic regression analysis was used to assess the independent variables that affect the development of neuropathy.
The prevalence of nephropathy is 54.3%. Longitudinal logistic regression identified four predictive variables on the development and progression of diabetic neuropathy that are: duration of diabetes, retinopathy, HbA1c at second visit, and creatinine clearance third visit.
Findings of this study show high prevalence of diabetic neuropathy. HbA1c and creatinine clearance are two modifiable risk factors for the development of diabetic neuropathy.
本研究旨在确定马来西亚医院环境中II型糖尿病患者糖尿病神经病变（DN）的危险因素和患病率。
采用观察性前瞻性纵向随访研究设计，通过招募马来西亚理科大学医院（HUSM）哥打巴鲁糖尿病门诊的1077名2型糖尿病门诊患者作为研究对象。神经病变的诊断通过神经传导研究得以确认。采用逻辑回归分析来评估影响神经病变发展的独立变量。
神经病变的患病率为54.3%。纵向逻辑回归确定了糖尿病神经病变发展和进展的四个预测变量，即：糖尿病病程、视网膜病变、第二次就诊时的糖化血红蛋白（HbA1c）以及第三次就诊时的肌酐清除率。
本研究结果显示糖尿病神经病变的患病率较高。糖化血红蛋白（HbA1c）和肌酐清除率是糖尿病神经病变发展的两个可改变的危险因素。
