Zhang Guo-qing, Han Feng, Fang Xin-zhi, Ma Xiao-mei
Lung Cancer Treatment Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China.
Zhonghua Zhong Liu Za Zhi. 2012 Aug;34(8):596-9. doi: 10.3760/cma.j.issn.0253-3766.2012.08.008.
To explore the expression of CD4(+), IL-17 and Foxp3 in non-small cell lung cancer (NSCLC) and their relationship with microvessel density (MVD).
The expressions of CD4(+), IL-17, Foxp3, CD31 and CD34 in the cancer tissues of 102 NSCLC cases were detected by immunohistochemisty. The relationship among the expressions of CD4(+), IL-17, Foxp3 and MVD was analyzed. The count data were analyzed using χ(2) test. The measurement data were analyzed using single-factor analysis of variance, and significance level α = 0.05.
Among the factors affecting CD31 expression, there was a statistically significant difference between the strong positive Foxp3 expression (++) and negative (-) and positive expressions (+) in the NSCLC cancer tissues (P < 0.05), and between the expressions in stage I and III cancer tissues (P < 0.05). Among the factors affecting CD34 expression, there was a significant difference between positive IL-7 expression (+) and strong positive IL-7 expression (++) (P < 0.05), between negative Foxp3 expression (-) and strong positive Foxp3 expression (++) (P < 0.05), and between the CD34 expressions in stage I and III and between those in stage II and III NSCLC cancer tissues (P < 0.05).
CD4, IL-17and Foxp3 may be involved in the tumor suppression caused by host immune response, and are related with the NSCLC invasion and metastasis.
探讨CD4(+)、白细胞介素-17（IL-17）和叉头框蛋白3（Foxp3）在非小细胞肺癌（NSCLC）中的表达及其与微血管密度（MVD）的关系。
采用免疫组织化学法检测102例NSCLC癌组织中CD4(+)、IL-17、Foxp3、CD31和CD34的表达。分析CD4(+)、IL-17、Foxp3表达与MVD之间的关系。计数资料采用χ(2)检验分析。计量资料采用单因素方差分析，检验水准α = 0.05。
在影响CD31表达的因素中，NSCLC癌组织中Foxp3强阳性表达（++）与阴性（-）及阳性表达（+）之间差异有统计学意义（P < 0.05），Ⅰ期与Ⅲ期癌组织中的表达之间差异有统计学意义（P < 0.05）。在影响CD34表达的因素中，IL-7阳性表达（+）与IL-7强阳性表达（++）之间差异有统计学意义（P < 0.05），Foxp3阴性表达（-）与Foxp3强阳性表达（++）之间差异有统计学意义（P < 0.05），NSCLC癌组织中Ⅰ期与Ⅲ期及Ⅱ期与Ⅲ期的CD34表达之间差异有统计学意义（P < 0.05）。
CD4、IL-17和Foxp3可能参与宿主免疫反应引起的肿瘤抑制，与NSCLC的侵袭和转移有关。
