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促炎细胞因子对非小细胞肺癌中IL-17RA表达的影响。

The effect of proinflammatory cytokines on IL-17RA expression in NSCLC.

作者信息

Huang Qi, Du Jiao, Fan Jinshuo, Lv Zhilei, Qian Xin, Zhang Xiuxiu, Han Jieli, Chen Caiyun, Wu Feng, Jin Yang

机构信息

Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei, People's Republic of China.

出版信息

Med Oncol. 2014 Sep;31(9):144. doi: 10.1007/s12032-014-0144-z. Epub 2014 Aug 12.

DOI:10.1007/s12032-014-0144-z
PMID:25112467
Abstract

Interleukin-17 receptor (IL-17RA) is essential for proinflammatory cytokine IL-17-mediated pathogenesis of various tumors. IL-17RA is upregulated by some proinflammatory cytokines such as IL-21 and IL-15 and downregulated by IL-2, while the effect of IL-1β, IL-6, IL-8, TNF-α on IL-17RA expression in non-small cell lung caner (NSCLC) remains unknown. Our findings revealed that IL-17RA mRNA was increased in NSCLC tissues compared with the corresponding peritumor tissues (P = 0.0039) and high expression of IL-17RA protein in human NSCLC tissues was significantly associated with histological subtype, primary tumor size and clinical stages (P = 0.033, 0.033 and 0.011, respectively). IL-17RA mRNA expression was positively related to IL-1β, IL-6, IL-8, TNF-α mRNA expression (P = 0.013, 0.0001, 0.002 and 0.010 respectively) in NSCLC tissues. Furthermore, IL-1β, IL-6, IL-8, TNF-α upregulated IL-17RA mRNA and protein in A549 and H460 cells (all P < 0.05). It is suggested that IL-1β, IL-6, IL-8, TNF-α promoted IL-17RA expression in NSCLC and they may involve in IL-17RA signaling in NSCLC.

摘要

白细胞介素-17受体（IL-17RA）对于促炎细胞因子IL-17介导的各种肿瘤发病机制至关重要。IL-17RA会被一些促炎细胞因子如IL-21和IL-15上调，而被IL-2下调，然而IL-1β、IL-6、IL-8、TNF-α对非小细胞肺癌（NSCLC）中IL-17RA表达的影响仍不清楚。我们的研究结果显示，与相应的肿瘤旁组织相比，NSCLC组织中IL-17RA mRNA增加（P = 0.0039），并且人NSCLC组织中IL-17RA蛋白的高表达与组织学亚型、原发肿瘤大小和临床分期显著相关（分别为P = 0.033、0.033和0.011）。在NSCLC组织中，IL-17RA mRNA表达与IL-1β、IL-6、IL-8、TNF-α mRNA表达呈正相关（分别为P = 0.013、0.0001、0.002和0.010）。此外，IL-1β、IL-6、IL-8、TNF-α上调了A549和H460细胞中IL-17RA mRNA和蛋白的表达（所有P < 0.05）。提示IL-1β、IL-6、IL-8、TNF-α促进了NSCLC中IL-17RA的表达，并且它们可能参与了NSCLC中的IL-17RA信号传导。

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