Ying Wang, Yingcong Yu, Liyi You, Liang Zheng
Department of Gastroenterology, Wenzhou People's Hospital, Wenzhou Zhejiang Province, 325000 PR, China.
Department of Ultrasonography, Wenzhou People's Hospital, Wenzhou Zhejiang Province, 325000 PR, China.
Open Life Sci. 2018 Apr 6;13:71-76. doi: 10.1515/biol-2018-0010. eCollection 2018 Jan.
The purpose of this study was to investigate the correlation between Interleukin 17 (IL-17) gene rs3748067 C>T polymorphism and gastric cancer risk through pooling the open published data.
Case-control or cohort studies relevant to IL-17 gene rs3748067 C>T polymorphism and gastric cancer susceptibility were systematic searched for in the databases of CNKI, Pubmed, Medline, Embase and Web of science. The association between IL-17 gene rs3748067 C>T polymorphism and gastric cancer risk were expressed with an odds ratio(OR) and 95% confidence interval (95% CI). Statistical heterogeneity across the studies was evaluated by I2 test. Publication bias was evaluated by Begg's funnel plot and Egger's line regression test.
Finally, seven case-control studies were included in our present study. Because of the statistical heterogeneity among the included studies for the aspects of dominant (TT+CT vs CC), recessive (TT vs CT+CC) and homozygous genetic model (TT vs CC), the data was pooled by random effect model. The pooled ORs were OR=0.99 (95% CI: 0.65-1.52), OR =1.23 (95% CI: 0.73-2.06 ) and OR=1.14 (95% CI: 0.58-2.27) for dominant, recessive and homozygous genetic model respectively. The pooled data indicated no correlation between IL-17 gene rs3748067 C>T polymorphism and gastric cancer risk. Significant publication bias was found in the dominant genetic model (p<0.05), but not in recessive and homozygous genetic model (p>0.05).
Based on the present evidence, there was no correlation between IL-17 gene rs3748067 C>T polymorphism and gastric cancer susceptibility in all genetic model. However, for the small sample size, significant heterogeneity and publication bias, the conclusion should be further evaluated through well designed case-control or cohort studies.
本研究旨在通过汇总已发表的公开数据，探讨白细胞介素17（IL-17）基因rs3748067 C>T多态性与胃癌风险之间的相关性。
在CNKI、Pubmed、Medline、Embase和Web of science数据库中系统检索与IL-17基因rs3748067 C>T多态性和胃癌易感性相关的病例对照研究或队列研究。IL-17基因rs3748067 C>T多态性与胃癌风险之间的关联用比值比（OR）和95%置信区间（95%CI）表示。通过I²检验评估各研究间的统计异质性。通过Begg漏斗图和Egger线性回归检验评估发表偏倚。
最终，本研究纳入了7项病例对照研究。由于纳入研究在显性（TT+CT vs CC）、隐性（TT vs CT+CC）和纯合子遗传模型（TT vs CC）方面存在统计异质性，故采用随机效应模型对数据进行合并。显性、隐性和纯合子遗传模型的合并OR分别为OR=0.99（95%CI：0.65-1.52）、OR =1.23（95%CI：0.73-2.06）和OR=1.14（95%CI：0.58-2.27）。合并数据表明IL-17基因rs3748067 C>T多态性与胃癌风险之间无相关性。显性遗传模型中发现显著的发表偏倚（p<0.05），而隐性和纯合子遗传模型中未发现（p>0.05）。
基于目前的证据，在所有遗传模型中，IL-17基因rs3748067 C>T多态性与胃癌易感性之间无相关性。然而，由于样本量小、显著的异质性和发表偏倚，该结论应通过设计良好的病例对照研究或队列研究进一步评估。
