Department of Cardiology, Hospital of the University of León, León, Spain.
Rev Cardiovasc Med. 2012;13(2-3):e62-9. doi: 10.3909/ricm0602.
Right ventricular systolic dysfunction (RVSD) has been related to prognosis in patients with heart failure (HF) and/or left ventricular systolic dysfunction. However, most of the studies addressing this issue are not large enough, have different inclusion criteria, and use different methods to evaluate RV function to draw definite conclusions. We sought to investigate the association between RVSD and outcomes in patients with left ventricular dysfunction. Eleven studies of 40 (27.5%), with 4732 patients, were included in the meta-analysis. RVSD was present in 2234 patients (47.2%). Four of the studies had admission for HF as an endpoint. We found a significant association between RVSD and overall mortality with significant between-studies heterogeneity and presence of publication bias (funnel plot). A significant association was found between RVSD and admission for HF. RVSD is associated with overall mortality and admission for HF during follow-up. Significant between-studies heterogeneity and publication bias must be taken into account when interpreting this information.
右心室收缩功能障碍（RVSD）与心力衰竭（HF）和/或左心室收缩功能障碍患者的预后相关。然而，大多数涉及此问题的研究规模不够大，纳入标准不同，并且使用不同的方法来评估 RV 功能，无法得出明确的结论。我们旨在研究 RVSD 与左心室功能障碍患者结局之间的关系。纳入了 11 项共 40 项研究（27.5%），共纳入 4732 例患者。RVSD 见于 2234 例患者（47.2%）。有 4 项研究以 HF 入院为终点。我们发现 RVSD 与全因死亡率之间存在显著关联，但存在研究间异质性和发表偏倚（漏斗图）。RVSD 与 HF 入院之间也存在显著关联。RVSD 与随访期间的全因死亡率和 HF 入院相关。在解释这些信息时，必须考虑到研究间异质性和发表偏倚。
