Department of Epidemiology, Harvard School of Public Health, Boston, USA.
BMJ. 2012 Nov 16;345:e7536. doi: 10.1136/bmj.e7536.
To compare the prognosis in women with interval breast cancer (cancer detected after a normal screening mammogram and before the next scheduled mammogram) with breast cancer detected among women not yet invited to mammography screening (non-screened).
Population based observational study.
Norwegian breast cancer screening programme, implemented in different counties from 1996 to 2005.
7116 women with a diagnosis of breast cancer at age 50 to 72 years; 1816 had interval breast cancer and 5300 had a diagnosis of breast cancer but had not yet been invited to screening.
Characteristics of the breast tumours, and survival of the women using Kaplan Meier curves and multivariable Cox proportional hazard models.
Although interval cancers on average were slightly larger than the cancers in women not invited to screening, the histological type or status of axillary lymph nodes did not differ noticeably between the two groups. Among interval cancers, there were no appreciable trends in size, nodal status, grade, or hormone receptor positivity associated with time since the last normal mammogram as a marker of growth rate. After 10 years of follow-up, the survival rates were 79.1% (95% confidence interval 75.4% to 82.3%) among women with interval cancers and 76.8% (75.3% to 78.2%) among women in the non-screened cancer group (hazard ratio 0.98, 95% confidence interval 0.84 to 1.15; P=0.53). Analyses stratified by time since last normal mammogram, age at diagnosis, or screening round showed similar results.
The prognosis of women with interval breast cancers was the same as that of women with breast cancers diagnosed without mammography screening.
比较间隔期乳腺癌（在正常筛查乳房 X 光照片和下一次预定乳房 X 光照片之间发现的癌症）与尚未接受乳房 X 光筛查的女性（未筛查）中发现的乳腺癌的预后。
基于人群的观察性研究。
1996 年至 2005 年在不同县实施的挪威乳腺癌筛查计划。
7116 名年龄在 50 至 72 岁之间诊断出乳腺癌的女性；1816 名患有间隔期乳腺癌，5300 名患有乳腺癌但尚未被邀请进行筛查。
使用 Kaplan-Meier 曲线和多变量 Cox 比例风险模型，评估女性乳房肿瘤的特征和生存情况。
尽管平均而言，间隔期癌症比未被邀请进行筛查的女性的癌症略大，但两组之间的组织学类型或腋窝淋巴结状态没有明显差异。在间隔期癌症中，没有明显的趋势表明自上次正常乳房 X 光照片以来的时间与肿瘤生长速度的标志物——肿瘤大小、淋巴结状态、分级或激素受体阳性率相关。随访 10 年后，间隔期乳腺癌患者的生存率为 79.1%（95%置信区间为 75.4%至 82.3%），未筛查癌症组的生存率为 76.8%（75.3%至 78.2%）（风险比 0.98，95%置信区间为 0.84 至 1.15；P=0.53）。按上次正常乳房 X 光照片时间、诊断时年龄或筛查轮次分层的分析结果相似。
间隔期乳腺癌女性的预后与未经乳房 X 光筛查诊断的乳腺癌女性相同。
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