Department of Radiology, C2-S, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Stroke. 2013 Jan;44(1):9-14. doi: 10.1161/STROKEAHA.112.671438. Epub 2012 Nov 15.
On MRI, cerebral white matter lesions, lacunar infarcts, and cerebral microbleeds are common imaging correlates of cerebral small vessel damage in apparently healthy elderly individuals. We investigated whether middle-aged to elderly offspring of nonagenarian siblings, who are predisposed to become long-lived as well, have a lower prevalence of white matter lesions, lacunar infarcts, and cerebral microbleeds than control subjects.
All subjects were from the Leiden Longevity Study. In this study, middle-aged to elderly offspring of nonagenarian siblings, who are predisposed to become long-lived as well, were contrasted to their spouses. Cerebral small vessel disease was assessed using 3-T MRI.
Offspring were less likely to have severe periventricular frontal caps (odds ratio [OR], 0.3; 95% confidence interval [CI], 0.1-1.1; P trend=0.01) and severe periventricular bands (OR, 0.4; 95% CI, 0.2-0.8; P trend=0.02). Moreover, offspring were less likely to have frontal (OR, 0.4; 95% CI, 0.2-0.9; P trend=0.05), parietal (OR, 0.4; 95% CI, 0.1-0.9; P trend=0.001), temporal (OR, 0.3; 95% CI, 0.1-0.8]; P trend=0.004), and occipital subcortical white matter lesions (OR, 0.3; 95% CI, 0.1-0.6; P trend=0.001). Prevalence of lacunar infarcts also was lower in offspring (OR, 0.3; 95% CI, 0.1-1.1; P=0.07). Prevalence of microbleeds was not significantly different in offspring and control subjects.
Exceptional familial longevity is associated with a lower susceptibility to white matter lesions and lacunar infarcts, but not cerebral microbleeds.
在 MRI 上，脑白质病变、腔隙性梗死和脑微出血是明显健康老年人脑小血管损伤的常见影像学相关表现。我们研究了是否中年到老年的非 90 岁高龄兄弟姐妹的后代也具有长寿倾向，其脑白质病变、腔隙性梗死和脑微出血的患病率是否低于对照组。
所有受试者均来自莱顿长寿研究。在这项研究中，具有长寿倾向的非 90 岁高龄兄弟姐妹的中年到老年后代与他们的配偶进行了对比。使用 3T MRI 评估脑小血管疾病。
后代发生严重的侧脑室额角帽状（比值比 [OR]，0.3；95%置信区间 [CI]，0.1-1.1；P 趋势=0.01）和严重的侧脑室带（OR，0.4；95%CI，0.2-0.8；P 趋势=0.02）的可能性较低。此外，后代发生额（OR，0.4；95%CI，0.2-0.9；P 趋势=0.05）、顶（OR，0.4；95%CI，0.1-0.9；P 趋势=0.001）、颞（OR，0.3；95%CI，0.1-0.8；P 趋势=0.004）和枕叶皮质下白质病变的可能性也较低（OR，0.3；95%CI，0.1-0.6；P 趋势=0.001）。后代腔隙性梗死的患病率也较低（OR，0.3；95%CI，0.1-1.1；P=0.07）。后代和对照组的微出血患病率无显著差异。
异常的家族长寿与脑白质病变和腔隙性梗死的易感性降低有关，但与脑微出血无关。
