联苯功能化含铕（II）穴合物与白蛋白的相互作用：对磁共振成像造影剂的启示
Interaction of Biphenyl-Functionalized Eu(2+)-Containing Cryptate with Albumin: Implications to Contrast Agents in Magnetic Resonance Imaging.
作者信息
Garcia Joel, Allen Matthew J
机构信息
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, USA.
出版信息
Inorganica Chim Acta. 2012 Dec 1;393:324-327. doi: 10.1016/j.ica.2012.07.006. Epub 2012 Jul 20.
Abstract
The influence of albumin on the efficacy of a Eu(2+)-containing complex capable of interacting with human serum albumin (HSA) was investigated at different field strengths (1.4, 3, 7, 9.4, and 11.7 T). Relaxometric measurements indicated that the presence of albumin at higher field strengths (>3 T) did not result in an increase in the relaxivity of the Eu(2+) complex, but a relaxation enhancement of 171 ± 11% was observed at 1.4 T. Titration experiments using different percentages (2, 4.5, 6, 10, 15, and 25% w/v) of HSA and variable-temperature (17)O NMR measurements were performed to understand the effect of albumin on the molecular properties of the biphenyl-functionalized Eu(2+) complex that are relevant to magnetic resonance imaging.
摘要
在不同场强（1.4、3、7、9.4和11.7 T）下，研究了白蛋白对一种能够与人血清白蛋白（HSA）相互作用的含Eu(2+)配合物疗效的影响。弛豫测量表明，在较高场强（>3 T）下白蛋白的存在并未导致Eu(2+)配合物弛豫率增加，但在1.4 T时观察到弛豫增强了171±11%。进行了使用不同百分比（2、4.5、6、10、15和25% w/v）的HSA的滴定实验以及变温(17)O NMR测量，以了解白蛋白对联苯功能化Eu(2+)配合物与磁共振成像相关的分子性质的影响。
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