用于磁共振和光声成像的氧化响应型、基于铕的多模态造影剂
Oxidation-Responsive, Eu-Based, Multimodal Contrast Agent for Magnetic Resonance and Photoacoustic Imaging.
作者信息
Basal Lina A, Yan Yan, Shen Yimin, Haacke E Mark, Mehrmohammadi Mohammad, Allen Matthew J
机构信息
Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
Department of Biomedical Engineering, Wayne State University , 818 W. Hancock, Detroit, Michigan 48201, United States.
出版信息
ACS Omega. 2017 Mar 31;2(3):800-805. doi: 10.1021/acsomega.6b00514. Epub 2017 Mar 6.
We report, for the first time, a multimodal, oxidation-responsive contrast agent for magnetic resonance imaging and photoacoustic imaging that uses the differences in the properties between Eu in the +2 and +3 oxidation states. The enhancement of contrast in -weighted magnetic resonance and photoacoustic imaging was observed in the +2 but not in the +3 oxidation state, and the complex is a known chemical exchange saturation transfer agent for magnetic resonance imaging in the +3 oxidation state.
我们首次报道了一种用于磁共振成像和光声成像的多模态、氧化响应性造影剂，它利用了铕（Eu）在 +2 和 +3 氧化态之间性质的差异。在 +2 氧化态下观察到了 T1 加权磁共振成像和光声成像中对比度的增强，而在 +3 氧化态下未观察到，并且该配合物在 +3 氧化态下是一种已知的用于磁共振成像的化学交换饱和转移剂。
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