通过碘在水相介质中促进吲哚的 C-H 氮芳基化反应实现高区域选择性的 C-N 键形成。

Highly regioselective C-N bond formation through C-H azolation of indoles promoted by iodine in aqueous media.

机构信息

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, China.

出版信息

Org Lett. 2012 Dec 7;14(23):5832-5. doi: 10.1021/ol302609m. Epub 2012 Nov 19.

DOI:10.1021/ol302609m

PMID:23163878

Abstract

An efficient and metal-free method for the direct C-N coupling of indoles with azoles to produce 2-(azol-1-yl)indoles in aqueous solution has been developed. This reaction proceeded highly regioselectively to provide a variety of indole derivatives with good to excellent yields.

摘要

开发了一种在水溶液中高效、无金属的吲哚与唑直接 C-N 偶联方法，以高产率得到多种吲哚衍生物。该反应具有高度区域选择性。