碘诱导的 N-保护吲哚的区域选择性 C-C 和 C-N 键形成。
Iodine-induced regioselective C-C and C-N bonds formation of N-protected indoles.
机构信息
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Chinese Academy of Science, Lanzhou 730000, People's Republic of China.
出版信息
J Org Chem. 2011 Jan 21;76(2):744-7. doi: 10.1021/jo1023014. Epub 2010 Dec 23.
A mild, metal-free, and environmently benign iodine-promoted regioselective C-C and C-N bonds formation of N-protected indole derivatives giving 2,3'-biindoles 2 and 4-(1H-indol-2-yl)morpholines 4 is successfully demonstrated. Various bioactive 2,3'-biindoles and 4-(1H-indol-2-yl)morpholines, bearing electron-rich to moderately electron-poor substituents, can be prepared in moderate to good yields.
成功演示了一种温和、无金属、环境友好的碘促进的 N-保护吲哚衍生物的区域选择性 C-C 和 C-N 键形成，得到 2,3'-双吲哚 2 和 4-(1H-吲哚-2-基)吗啉 4。可以中等至良好的收率制备各种具有富电子到中等缺电子取代基的生物活性 2,3'-双吲哚和 4-(1H-吲哚-2-基)吗啉。
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