Goto K, Yasue H, Okumura K, Matsuyama K, Kugiyama K, Miyagi H, Higashi T
Division of Cardiology, Kumamoto University Medical School, Japan.
Am J Cardiol. 1990 Mar 15;65(11):709-12. doi: 10.1016/0002-9149(90)91375-g.
To study whether magnesium (Mg) deficiency is present in patients with variant angina, 24-hour Mg retention of low dose Mg (0.2 mEq/kg lean body weight) administered intravenously over 4 hours in 20 patients with variant angina was examined. No patient had received calcium antagonists before or during the study. All had attacks of chest pain associated with ST elevation on electrocardiograms. Twenty-one subjects without ischemic heart disease were studied as control subjects. Ten patients with variant angina were restudied 10 to 529 days (mean 235 +/- 30) after the treatment with calcium antagonists (diltiazem 120 to 240 or nifedipine 40 to 80 mg/day), which resulted in complete suppression of anginal attacks. The mean serum Mg concentrations in the patients with variant angina and the control subjects were 2.1 +/- 0.05 and 2.1 +/- 0.03 mg/dl, respectively (difference not significant). However, 24-hour Mg retention in the patients with variant angina was 60 +/- 5%, while that in the control subjects was 36 +/- 3% (p less than 0.001), suggesting that Mg deficiency is present in at least some patients with variant angina. The mean serum Mg concentrations before and after calcium antagonist treatment in 10 patients with variant angina were 2.1 +/- 0.09 and 2.1 +/- 0.07 mg/dl, respectively (difference not significant). However, 24-hour Mg retention decreased significantly (p less than 0.01) from 60 +/- 6 to 34 +/- 7% after the treatment. There is Mg deficiency in many patients with variant angina and it is corrected after treatment with calcium antagonists.
为研究变异型心绞痛患者是否存在镁（Mg）缺乏，对20例变异型心绞痛患者静脉输注低剂量镁（0.2 mEq/kg瘦体重）4小时后的24小时镁潴留情况进行了检测。研究前及研究期间所有患者均未接受过钙拮抗剂治疗。所有患者均有与心电图ST段抬高相关的胸痛发作。选取21例无缺血性心脏病的受试者作为对照。10例变异型心绞痛患者在接受钙拮抗剂（地尔硫卓120至240 mg/天或硝苯地平40至80 mg/天）治疗使心绞痛发作完全得到控制后10至529天（平均235±30天）进行了再次研究。变异型心绞痛患者和对照受试者的平均血清镁浓度分别为2.1±0.05和2.1±0.03 mg/dl（差异无统计学意义）。然而，变异型心绞痛患者的24小时镁潴留率为60±5%，而对照受试者为36±3%（p<0.001），提示至少部分变异型心绞痛患者存在镁缺乏。10例变异型心绞痛患者在接受钙拮抗剂治疗前后的平均血清镁浓度分别为2.1±0.09和2.1±0.07 mg/dl（差异无统计学意义）。然而，治疗后24小时镁潴留率从60±6%显著降低至34±7%（p<0.01）。许多变异型心绞痛患者存在镁缺乏，且在接受钙拮抗剂治疗后得到纠正。
