Satake K, Lee J D, Shimizu H, Ueda T, Nakamura T
First Department of Internal Medicine, Fukui Medical School, Japan.
J Am Coll Cardiol. 1996 Oct;28(4):897-902. doi: 10.1016/s0735-1097(96)00256-2.
We evaluated whether the severity of magnesium deficiency was correlated with the frequency of attacks of variant angina.
Magnesium deficiency may be associated with the development of variant angina. However, the relation between the activity of variant angina and magnesium deficiency remains to be elucidated.
We assessed the body magnesium status of 18 men with variant angina: Group 1 (> or = 4 attacks/week, n = 7) and Group 2 (< 4 attacks/week, n = 11). Concentrations of magnesium were determined in serum, urine, mononuclear cells and erythrocytes, and the 24-h magnesium retention rate was determined.
Group 1 showed a higher 24-h magnesium retention rate (mean +/- SEM 63.5 +/- 7.6% vs. 24.9 +/- 2.7%, p < 0.01) and a lower intracellular concentration of magnesium in mononuclear cells and erythrocytes than did Group 2 (respectively, 156.3 +/- 13.5 vs. 212.1 +/- 6.9 fg/cell, p < 0.01; and 3.5 +/- 0.5 vs. 5.2 +/- 0.4 fg/cell, p < 0.05), demonstrating the presence of magnesium deficiency in Group 1. The 24-h magnesium retention rate and intracellular concentrations of magnesium in mononuclear cells and erythrocytes correlated well with the frequency of anginal attacks (r = 0.78, p < 0.01; r = -0.78, p < 0.01; r = -0.62, p < 0.01, respectively) for all patients.
Data suggest that the magnesium status of men with variant angina is closely related to disease activity.
我们评估了镁缺乏的严重程度是否与变异型心绞痛的发作频率相关。
镁缺乏可能与变异型心绞痛的发生有关。然而，变异型心绞痛的活动与镁缺乏之间的关系仍有待阐明。
我们评估了18名变异型心绞痛男性患者的体内镁状态：第1组（每周发作≥4次，n = 7）和第2组（每周发作<4次，n = 11）。测定血清、尿液、单核细胞和红细胞中的镁浓度，并测定24小时镁潴留率。
第1组的24小时镁潴留率较高（平均±标准误63.5±7.6% 对24.9±2.7%，p < 0.01），且单核细胞和红细胞中的细胞内镁浓度低于第2组（分别为156.3±13.5对212.1±6.9 fg/细胞，p < 0.01；以及3.5±0.5对5.2±0.4 fg/细胞，p < 0.05），表明第1组存在镁缺乏。所有患者的24小时镁潴留率以及单核细胞和红细胞中的细胞内镁浓度与心绞痛发作频率密切相关（r分别为0.78，p < 0.01；r为 -0.78，p < 0.01；r为 -0.62，p < 0.01）。
数据表明变异型心绞痛男性患者的镁状态与疾病活动密切相关。
