镰状细胞病唾液腺的定量 MRI 分析。
Quantitative MRI analysis of salivary glands in sickle cell disease.
机构信息
Department of Radiology, Boston Medical Center, Boston University School of Medicine, Joseph Liao, 86 Saint Botolph St, #13, Boston, MA 02116, USA.
出版信息
Dentomaxillofac Radiol. 2012 Dec;41(8):630-6. doi: 10.1259/dmfr/31672000.
OBJECTIVES
The purpose of this prospective study was to characterize the MR relaxometric features of the major salivary glands in patients with sickle cell disease (SCD).
METHODS
15 patients with SCD (aged 19.8-43.6 years) and 12 controls were imaged with the mixed turbo-spin echo pulse sequence. The major salivary glands were manually segmented and T1, T2 and secular T2 relaxometry histograms were modelled with Gaussian functions.
RESULTS
Shortened T1 relaxation times were seen solely in the submandibular glands of patients with SCD (747.5±54.8 ms vs 807.1±38.3 ms, p<0.001). Slight T2 and secular T2 shortening were seen in the parotid gland; however, this difference was not significant (p=0.07). The sublingual gland showed no changes under MR relaxometry. There was no difference in glandular volumes, and no correlation was demonstrated between history of blood transfusion and salivary gland relaxometry.
CONCLUSIONS
Patients with SCD exhibited changes in quantitative MRI T1 relaxometry histograms of the submandibular glands.
目的
本前瞻性研究旨在描述镰状细胞病（SCD）患者主要唾液腺的 MR 弛豫特征。
方法
对 15 例 SCD 患者（年龄 19.8-43.6 岁）和 12 名对照者进行混合涡轮自旋回波脉冲序列成像。手动分割主要唾液腺，并使用高斯函数对 T1、T2 和瞬态 T2 弛豫时间直方图进行建模。
结果
仅在 SCD 患者的下颌下腺中观察到 T1 弛豫时间缩短（747.5±54.8 ms 比 807.1±38.3 ms，p<0.001）。腮腺中 T2 和瞬态 T2 稍有缩短，但差异无统计学意义（p=0.07）。舌下腺在 MR 弛豫时间测定中无变化。腺体体积无差异，输血史与唾液腺弛豫时间之间也无相关性。
结论
SCD 患者下颌下腺的定量 MRI T1 弛豫时间直方图发生改变。
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