谷胱甘肽S-转移酶M3基因多态性与肺癌易感性之间缺乏关联。

Lack of association of glutathione S-transferase M3 gene polymorphism with the susceptibility of lung cancer.

作者信息

Feng Xu, Dong Chun-Qiang, Shi Jun-Jie, Zhou Hua-Fu, He Wei, Zheng Bao-Shi

机构信息

Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, NanNing, China.

出版信息

Asian Pac J Cancer Prev. 2012;13(9):4465-8. doi: 10.7314/apjcp.2012.13.9.4465.

DOI:10.7314/apjcp.2012.13.9.4465

PMID:23167362

Abstract

OBJECTIVE

The conclusions of published reports on the relationship between the glutathione S-transferase M3 (GSTM3) A/B gene polymorphism and the risk of lung cancer are still debated. This meta-analysis was performed to evaluate the association between GSTM3 and the risk of lung cancer.

METHODS

Association investigations were identified from PubMed, Embase, and Cochrane Library, and eligible studies were included and synthesized using a meta-analysis method.

RESULTS

Eight reports were included into this meta-analysis for the association of GSTM3 A/B gene polymorphism and lung cancer susceptibility, covering 1,854 patients with lung cancer and 1,926 controls. No association between the GSTM3 A/B gene polymorphism and lung cancer was found in this meta-analysis (B allele: OR = 1.25, 95% CI: 0.89-1.76, P = 0.20; BB genotype: OR = 1.53, 95% CI: 0.71-3.32, P = 0.28; AA genotype: OR = 0.85, 95% CI: 0.59-1.23, P = 0.39).

CONCLUSIONS

The GSTM3 A/B gene polymorphism is not associated with lung cancer susceptibility. However, more studies on the relationship between GSTM3 A/B gene polymorphism and the risk of lung cancer should be performed in the future.

摘要

目的

已发表的关于谷胱甘肽S-转移酶M3（GSTM3）A/B基因多态性与肺癌风险之间关系的报告结论仍存在争议。本荟萃分析旨在评估GSTM3与肺癌风险之间的关联。

方法

从PubMed、Embase和Cochrane图书馆中识别关联研究，并纳入符合条件的研究，采用荟萃分析方法进行综合分析。

结果

本荟萃分析纳入了8篇关于GSTM3 A/B基因多态性与肺癌易感性关联的报告，涵盖1854例肺癌患者和1926例对照。本荟萃分析未发现GSTM3 A/B基因多态性与肺癌之间存在关联（B等位基因：OR = 1.25，95% CI：0.89 - 1.76，P = 0.20；BB基因型：OR = 1.53，95% CI：0.71 - 3.32，P = 0.28；AA基因型：OR = 0.85，95% CI：0.59 - 1.23，P = 0.39）。