Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Mol Biol Rep. 2012 Dec;39(12):10313-23. doi: 10.1007/s11033-012-1908-1. Epub 2012 Oct 13.
The conclusions of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the risk of lung cancer are still debated. GSTP1 is one of the important mutant sites reported at present. This meta-analysis was performed to evaluate the association between GSTP1 and the risk of lung cancer. The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. Forty-four reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and lung cancer susceptibility, consisting of 12,363 patients with lung cancer and 13,948 controls. The association between GSTPI G allele and lung cancer risk was found in this meta-analysis (OR 1.08, 95 % CI 1.02-1.15, P = 0.01). However, the GG genotype and AA genotype were not associated with the susceptibility of lung cancer. Furthermore, there was no association between GSTP1 A/G gene polymorphism and the risk of lung cancer in Caucasians, and East-Asians. In conclusion, GSTP1 G allele is associated with the lung cancer susceptibility. However, more studies on the relationship between GSTP1 A/G gene polymorphism and the risk of lung cancer should be performed in the future.
目前已报道谷胱甘肽 S-转移酶 P1（GSTP1）基因多态性与肺癌风险之间的关系的结论仍存在争议。GSTP1 是目前报道的重要突变位点之一。本荟萃分析旨在评估 GSTP1 与肺癌风险之间的关系。通过 PubMed 和 Cochrane Library 确定了关联研究，并使用荟萃分析方法纳入并综合了符合条件的研究。有 44 项研究纳入了 GSTP1 A/G 基因多态性与肺癌易感性的关联分析，包括 12363 例肺癌患者和 13948 例对照。荟萃分析发现 GSTPI G 等位基因与肺癌风险相关（OR 1.08，95%CI 1.02-1.15，P=0.01）。然而，GG 基因型和 AA 基因型与肺癌易感性无关。此外，在白种人和东亚人群中，GSTP1 A/G 基因多态性与肺癌风险之间没有关联。总之，GSTP1 G 等位基因与肺癌易感性相关。然而，未来应该进行更多关于 GSTP1 A/G 基因多态性与肺癌风险之间关系的研究。
