谷胱甘肽 S-转移酶 P1 基因多态性与肺癌腺癌风险的关联的荟萃分析。
A meta-analysis of the association between glutathione S-transferase P1 gene polymorphism and the risk of adenocarcinomas of lung cancer.
机构信息
Department of Cardio-Thoracic Surgery, People's Hospital of Beihai, Beihai, China.
出版信息
Cancer Biomark. 2013;13(1):29-35. doi: 10.3233/CBM-130322.
BACKGROUND
Results of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the adenocarcinomas of lung cancer are still debated.
OBJECTIVE
This meta-analysis was performed to evaluate the association between GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer.
METHODS
The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method.
RESULTS
16 reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of adenocarcinomas. Furthermore, in the sensitivity analysis, the results were similar with those from the non-sensitivity analysis.
CONCLUSIONS
GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer.
背景
关于谷胱甘肽 S-转移酶 P1（GSTP1）基因多态性与肺癌腺癌之间的关系的已发表报告的结果仍存在争议。
目的
本荟萃分析旨在评估 GSTP1 A/G 基因多态性与肺癌腺癌风险之间的关联。
方法
从 PubMed 和 Cochrane Library 中确定了关联研究，并使用荟萃分析方法纳入并综合了符合条件的研究。
结果
这项荟萃分析纳入了 16 项关于 GSTP1 A/G 基因多态性与肺癌腺癌风险的关联研究。G 等位基因和 GG 基因型与腺癌风险的易感性无关。此外，在敏感性分析中，结果与非敏感性分析相似。
结论
GSTP1 G 等位基因或 GG 基因型不是与肺癌腺癌易感性相关的生物标志物。
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