Rahman M, Shahid N S, Rahman H, Sack D A, Rahman N, Hossain S
Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh.
Am J Trop Med Hyg. 1990 Feb;42(2):127-30. doi: 10.4269/ajtmh.1990.42.127.
Fecal samples from diarrheal patients and non-diarrheal controls were examined for Cryptosporidium oocysts in a year-long prospective study at a diarrhea treatment center in Dhaka, Bangladesh. Cryptosporidium oocysts were detected in 42 (3%) of 1,382 diarrheal patients but in none of 235 non-diarrheal controls. In 32 (76%) of 42 patients, no other enteropathogens were detected. Children less than 5 years of age were more commonly infected than older children (4.8% vs. 1.6%, P greater than 0.05) and adults (4.8% vs. 0.2%, P less than 0.01). A higher number of cases were detected during hot and humid months (April--July). Nineteen children less than 5 years of age (index cases) and their 71 family members were followed for 3 weeks after the release of the index cases from the hospital. Diarrhea continued for greater than 14 days (persistent diarrhea) in 8 (32%) index children. Cryptosporidium oocysts were detected in 1 (12.5%) of 8 family members who developed diarrhea during the follow-up period. Index cases excreted oocysts for 3-28 days (12.37 +/- 8.35 days). Almost all the patients recovered with oral rehydration. Cryptosporidium ssp. cause self-limited diarrhea episodes in children less than 5 years of age in Bangladesh, with a low frequency of intrafamilial transmission.
在孟加拉国达卡的一家腹泻治疗中心进行的为期一年的前瞻性研究中，对腹泻患者和非腹泻对照者的粪便样本进行了隐孢子虫卵囊检测。1382例腹泻患者中有42例（3%）检测到隐孢子虫卵囊，而235例非腹泻对照者中均未检测到。42例患者中有32例（76%）未检测到其他肠道病原体。5岁以下儿童比大龄儿童（4.8%对1.6%，P>0.05）和成人（4.8%对0.2%，P<0.01）更易感染。在炎热潮湿的月份（4月至7月）检测到的病例数更多。19名5岁以下儿童（索引病例）及其71名家庭成员在索引病例出院后随访3周。8名（32%）索引儿童腹泻持续超过14天（持续性腹泻）。在随访期间出现腹泻的8名家庭成员中有1名（12.5%）检测到隐孢子虫卵囊。索引病例排出卵囊的时间为3至28天（12.37±8.35天）。几乎所有患者通过口服补液得以康复。在孟加拉国，隐孢子虫属可导致5岁以下儿童出现自限性腹泻发作，家庭内传播频率较低。
