National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, Beijing, P.R. China.
Am J Med Genet B Neuropsychiatr Genet. 2013 Jan;162B(1):36-43. doi: 10.1002/ajmg.b.32116. Epub 2012 Nov 20.
Compelling evidence suggests that there is a considerable overlap in structural and functional alternation in the brain between different neuropsychiatric disorders. However, whether these overlaps are specific for schizophrenia has yet to be investigated. A total of 36 patients with paranoid schizophrenia, 43 patients with major depressive disorder (MDD), and 44 healthy controls were recruited to undergo resting-state functional magnetic resonance imaging (rs-fMRI) for analysis of regional homogeneity (ReHo). Twelve regions of interest (ROIs) in the frontal and temporal lobes were generated and one-way ANOVA was performed to test the ReHo differences within these ROIs between the above three groups. The ReHo values within ROIs were extracted to investigate whether a left-right asymmetry existed in a mental disorder. One-way ANOVA showed significant differences in ReHo in the right superior frontal gyrus and left superior temporal gyrus; post hoc analysis revealed that schizophrenic patients had lower ReHo in the left superior temporal gyrus than either control subjects or patients with MDD. Increased ReHo was observed in the right superior frontal gyrus in schizophrenic patients compared with control subjects, and a left-less-than-right asymmetry was also found in this region in schizophrenic patients. The above alterations in ReHo were not affected by age and genders. Our study suggests that the altered ReHo in the superior frontal and temporal gyrus may be specific for schizophrenia rather than MDD. A left-less-than-right asymmetry activation pattern may exist in the resting-state superior frontal gyrus in schizophrenia. This finding would be helpful for better understanding the pathological mechanisms of schizophrenia.
大量证据表明，不同神经精神疾病之间的大脑结构和功能改变存在相当大的重叠。然而，这些重叠是否是精神分裂症所特有的，尚未得到研究。共招募了 36 名偏执型精神分裂症患者、43 名重度抑郁症（MDD）患者和 44 名健康对照者进行静息态功能磁共振成像（rs-fMRI）分析局部一致性（ReHo）。生成了额颞叶的 12 个感兴趣区（ROIs），并对上述三组患者的 ROI 内 ReHo 差异进行单因素方差分析。提取 ROI 内的 ReHo 值，以探讨精神障碍是否存在左右不对称性。单因素方差分析显示，右侧额上回和左侧颞上回的 ReHo 存在显著差异；事后分析显示，精神分裂症患者左侧颞上回的 ReHo 低于对照组和 MDD 患者。与对照组相比，精神分裂症患者右侧额上回的 ReHo 增加，并且在该区域也发现了左侧小于右侧的不对称性。ReHo 的上述改变不受年龄和性别影响。我们的研究表明，额颞叶上回 ReHo 的改变可能是精神分裂症特有的，而不是 MDD。在精神分裂症中，静息状态下额上回可能存在左侧小于右侧的激活模式。这一发现有助于更好地理解精神分裂症的病理机制。
