Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi- 110025, India.
Mini Rev Med Chem. 2013 Apr;13(4):522-9. doi: 10.2174/1389557511313040005.
The emergence of nanotechnology has changed the scenario of the medical world by revolutionizing the diagnosis, monitoring and treatment of cancer. This nanotechnology has been proved miraculous in detecting cancer cells, delivering chemotherapeutic agents and monitoring treatment from non-specific to highly targeted killing of tumor cells. In the past few decades, a number of inorganic materials have been investigated such as calcium phosphate, gold, carbon materials, silicon oxide, iron oxide, and layered double hydroxide (LDH) for examining their efficacy in targeting drug delivery. The reason behind the selection of these inorganic materials was their versatile and unique features efficient in drug delivery, such as wide availability, rich surface functionality, good biocompatibility, potential for target delivery, and controlled release of the drug from these inorganic nanomaterials. Although, the drug-LDH hybrids are found to be quite instrumental because of their application as advanced anti-cancer drug delivery systems, there has not been much research on them. This mini review is set to highlight the advancement made in the use of layered double hydroxides (LDHs) as anti-cancer drug delivery agents. Along with the advantages of LDHs as anti-cancer drug delivery agents, the process of interaction of some of the common anti-cancer drugs with LDH has also been discussed.
纳米技术的出现通过革新癌症的诊断、监测和治疗改变了医学领域的格局。这种纳米技术在检测癌细胞、输送化疗药物以及监测治疗方面已被证明具有神奇的效果，它可以实现从非特异性到高度靶向肿瘤细胞杀伤的转变。在过去几十年中，已经研究了许多无机材料，如磷酸钙、金、碳材料、氧化硅、氧化铁和层状双氢氧化物（LDH），以考察它们在靶向药物递送方面的功效。选择这些无机材料的原因是它们具有多功能和独特的特性，非常适合药物输送，例如广泛的可用性、丰富的表面功能、良好的生物相容性、靶向递送的潜力以及从这些无机纳米材料中控制药物的释放。尽管由于其作为先进抗癌药物递送系统的应用，药物-LDH 杂化物被发现非常有效，但对它们的研究还不多。本篇迷你综述旨在强调将层状双氢氧化物（LDHs）用作抗癌药物递送剂方面的进展。除了 LDHs 作为抗癌药物递送剂的优势外，还讨论了一些常见抗癌药物与 LDH 相互作用的过程。
