State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, P.O. Box 98, Beijing 100029, China.
Pharmaceutics. 2014 Jun 17;6(2):298-332. doi: 10.3390/pharmaceutics6020298.
Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize intercalated structures have a significant influence on the development of new applications of these materials. We also show how modification and/or functionalization can lead to new biotechnological and biomedical applications. This review highlights the most recent progresses in research on LDH-based controlled drug delivery systems, focusing mainly on: (i) DDS with cardiovascular drugs as guests; (ii) DDS with anti-inflammatory drugs as guests; and (iii) DDS with anti-cancer drugs as guests. Finally, future prospects for LDH-based drug carriers are also discussed.
作为高效的药物输送系统 (DDS)，生物相容的粘土材料引起了特别关注。在本文中，我们综述了层状双氢氧化物 (LDHs) 在控制药物释放和输送中的应用进展。我们展示了合成插层结构能力的提高如何对这些材料的新应用的发展产生重大影响。我们还展示了修饰和/或功能化如何导致生物技术和生物医学应用的新发展。本综述重点介绍了基于 LDH 的控释药物输送系统研究的最新进展，主要包括：（i）以心血管药物为客体的 DDS；（ii）以抗炎药物为客体的 DDS；以及（iii）以抗癌药物为客体的 DDS。最后，还讨论了基于 LDH 的药物载体的未来前景。
