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2,4-甲苯二胺对大鼠和小鼠致癌作用及剂量反应关系与甲苯二异氰酸酯的统计学比较。

Statistical Comparison of Carcinogenic Effects and Dose-Response Relationships in Rats and Mice for 2,4-Toluene Diamine to those Ascribed to Toluene Diisocyanate.

作者信息

Sielken Robert L, Bretzlaff Robert S, Valdez-Flores Ciriaco, Parod Ralph

机构信息

Sielken & Associates Consulting, Inc., Bryan, TX, USA.

出版信息

Hum Ecol Risk Assess. 2012 Nov;18(6):1315-1337. doi: 10.1080/10807039.2012.722853. Epub 2012 Nov 6.

DOI:10.1080/10807039.2012.722853
PMID:23172986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3498838/
Abstract

The U.S. National Toxicology Program (NTP) conducted 2-year bioassays of commercial grade toluene diisocyanate (TDI) (80% 2,4-TDI and 20% 2,6-TDI) and 2,4-toluene diamine (TDA) and concluded that both were carcinogenic in rodents. In the TDI study, there was an unproven but likely formation of TDA either because of flawed test-substance handling and storage conditions and/or the atypical exposure conditions employed. Although the carcinogenic responses in both studies were qualitatively similar, several statistical analyses were performed to substantiate this possibility more rigorously. Seven different statistical approaches combine to yield a robust and consistent conclusion that, if only a small fraction (approximately 5%) of the dose of TDI were hydrolyzed to TDA in the TDI study, then that would be sufficient to explain the observed carcinogenic responses in the TDI study.

摘要

美国国家毒理学计划（NTP）对商业级甲苯二异氰酸酯（TDI）（80% 2,4 - TDI和20% 2,6 - TDI）和2,4 - 甲苯二胺（TDA）进行了为期两年的生物测定，并得出结论：两者在啮齿动物中均具有致癌性。在TDI研究中，由于测试物质处理和储存条件存在缺陷和/或采用了非典型暴露条件，存在未经证实但可能的TDA形成情况。尽管两项研究中的致癌反应在性质上相似，但进行了几项统计分析以更严格地证实这种可能性。七种不同的统计方法结合起来得出了一个有力且一致的结论：在TDI研究中，如果只有一小部分（约5%）的TDI剂量水解为TDA，那么这就足以解释TDI研究中观察到的致癌反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ab/3498838/70457da67171/bher18_1315_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ab/3498838/6b3bae0f4edc/bher18_1315_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ab/3498838/5bcf299d18b8/bher18_1315_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ab/3498838/70457da67171/bher18_1315_f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ab/3498838/6b3bae0f4edc/bher18_1315_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ab/3498838/5bcf299d18b8/bher18_1315_f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61ab/3498838/70457da67171/bher18_1315_f3.jpg

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