Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
Neurosurg Clin N Am. 2013 Jan;24(1):67-78. doi: 10.1016/j.nec.2012.08.010.
Sarcomas of the head, neck, and skull base represent a heterogeneous group of tumors with distinct prognostic features. There have been significant improvements in characterizing these sarcomas using traditional morphologic assessments and more recent immunohistochemical analysis. Surgery is the mainstay of treatment followed by radiation therapy. Treatment modalities have changed in select pediatric sarcomas, for which new chemotherapeutic combinations have improved survival statistics. The high rate of distant failure emphasizes the need for novel systemic and directed molecular therapies. Tumor grade, size, and margin status are key factors in survival.
头颈部和颅底肉瘤是一组具有不同预后特征的异质性肿瘤。使用传统的形态学评估和最近的免疫组织化学分析，对这些肉瘤的特征进行了显著的改善。手术是主要的治疗方法，其次是放射治疗。在某些儿科肉瘤中，治疗方式已经发生了变化，新的化疗联合治疗提高了生存率。远处转移失败率高，强调需要新的系统性和靶向分子治疗。肿瘤分级、大小和切缘状态是生存的关键因素。
