低级别与高级别头颈部多形性皮肤肉瘤的生存差异及1例头皮病例报告
Survival differences of low-grade versus high-grade head and neck pleomorphic dermal sarcomas and a review of a scalp case.
作者信息
Janz Tyler A, Long Barry D, Joshi Rohan R, Coblens Orly M
机构信息
Department of Otolaryngology-Head and Neck Surgery University of Texas Medical Branch Galveston Texas USA.
出版信息
World J Otorhinolaryngol Head Neck Surg. 2022 Apr 18;9(1):74-78. doi: 10.1002/wjo2.64. eCollection 2023 Mar.
OBJECTIVE
To examine survival by tumor grade of pleomorphic dermal sarcomas (PDS) of the head and neck (H&N) and review a scalp PDS case.
METHODS
Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1980 to 2016 based on a diagnosis of H&N PDS. Survival estimates were performed using Kaplan-Meier analysis. Additionally, a case of a grade III H&N PDS is presented.
RESULTS
Two hundred-seventy cases of PDS were identified. The mean age at diagnosis was 75.1 years (SD: 13.5). Two hundred-thirty-four (86.7%) patients were male. Eighty-seven percent of patients received surgery as a part of their care. The 5-year overall survival rates for grades I, II, III, and IV PDSs were 69%, 60%, 50%, and 42%, respectively ( = 0.03).
CONCLUSIONS
H&N PDS occurs most commonly in older-age males. Surgical management is frequently a part of H&N PDS care. Survival rates significantly decline based on tumor grade.
目的
研究头颈部多形性皮肤肉瘤（PDS）的肿瘤分级与生存率，并回顾1例头皮PDS病例。
方法
纳入监测、流行病学和最终结果（SEER）数据库中1980年至2016年诊断为头颈部PDS的患者。采用Kaplan-Meier分析进行生存估计。此外，还报告1例III级头颈部PDS病例。
结果
共识别出270例PDS病例。诊断时的平均年龄为75.1岁（标准差：13.5）。234例（86.7%）患者为男性。87%的患者接受了手术治疗。I级、II级、III级和IV级PDS的5年总生存率分别为69%、60%、50%和42%（P = 0.03）。
结论
头颈部PDS最常见于老年男性。手术治疗常是头颈部PDS治疗的一部分。生存率随肿瘤分级显著下降。
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