NLRC5：MHC I 类依赖性免疫反应的关键调节因子。
NLRC5: a key regulator of MHC class I-dependent immune responses.
机构信息
Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M Health Science Center, College Station, Texas 77843, USA.
出版信息
Nat Rev Immunol. 2012 Dec;12(12):813-20. doi: 10.1038/nri3339.
The expression of MHC class I molecules is crucial for the initiation and regulation of adaptive immune responses against pathogens. NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II transactivator (CIITA), interact with similar MHC promoter-bound factors. Here, we provide a broad overview of the molecular mechanisms behind MHC class I transcription and the role of the class I transactivator NLRC5 in MHC class I-dependent immune responses.
MHC I 类分子的表达对于启动和调节针对病原体的适应性免疫反应至关重要。NOD、LRR 和 CARD 结构域包含蛋白 5（NLRC5）最近被鉴定为 MHC I 类基因（CITA）的特异性转录激活子。NLRC5 和 MHC II 类基因的主要调节因子，即 II 类转录激活物（CIITA），与类似的 MHC 启动子结合因子相互作用。在这里，我们提供了 MHC I 类转录背后的分子机制以及 NLRC5 在 MHC I 类依赖性免疫反应中的作用的广泛概述。
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