Department of Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, College Station, TX, USA.
Immunology. 2021 Mar;162(3):252-261. doi: 10.1111/imm.13235. Epub 2020 Aug 3.
The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class-I-related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5-dependent MHC class I expression.
主要组织相容性复合体 (MHC) Ⅰ类和Ⅱ类分子呈递抗原肽对于适应性免疫系统的激活至关重要。核苷酸结合域和富含亮氨酸重复受体家族成员 CIITA 和 NLRC5 分别作为 MHC Ⅱ类和Ⅰ类基因表达的主要转录激活因子发挥作用。自从 NLRC5 被鉴定为 MHC Ⅰ类和Ⅰ类相关基因的主调控因子以来，人们对 NLRC5 在传染病和癌症中的功能有了更深入的了解。在这里，我们讨论了 NLRC5 依赖性 MHC Ⅰ类表达的生物学意义和机制。
