白尾鹿慢性消耗病的气溶胶传播。
Aerosol transmission of chronic wasting disease in white-tailed deer.
机构信息
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
出版信息
J Virol. 2013 Feb;87(3):1890-2. doi: 10.1128/JVI.02852-12. Epub 2012 Nov 21.
Abstract
While the facile transmission of chronic wasting disease (CWD) remains incompletely elucidated, studies in rodents suggest that exposure of the respiratory mucosa may be an efficient pathway. The present study was designed to address this question in the native cervid host. Here, we demonstrate aerosol transmission of CWD to deer with a prion dose >20-fold lower than that used in previous oral inoculations. Inhalation of prions may facilitate transmission of CWD and, perhaps, other prion infections.
摘要
虽然慢性消瘦病（CWD）的易传播机制仍不完全清楚，但啮齿动物研究表明，呼吸道黏膜暴露可能是一种有效的途径。本研究旨在解决在本地鹿宿主中的这一问题。在这里，我们证明了 CWD 通过气溶胶传播给鹿，其朊病毒剂量比以前的口服接种低 20 多倍。吸入朊病毒可能促进 CWD 及其他朊病毒感染的传播。
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