Bourry J, Lagrange J L, Chauvel P, François E, Abbes M, Monticelli J
Centre Antoine-Lacassagne, Nice, France.
Bull Cancer. 1990;77(2):117-21.
We present 12 patients (3 male, 9 female) aged from 53-88 years with squamous cell cancer of the anal canal treated with combined radiotherapy-chemotherapy (5 FU-mitomycin C); the distribution of the tumours was 2 T4, 6 T3, 3 T2, 1 T1). In 11 patients evaluated, complete remission was obtained in 8 with partial remission in 2 others. In spite of this good result with combined treatment, 4 patients had a recurrence between 9 and 26 months. Five patients survived and 2 died without disease (16-38 month), 3 patients died and one survived with disease. The small series confirms the efficacy of this combination which treated bulky tumours (T3-T4). It is necessary however to compare these results with radiation alone in a randomised trial.
我们报告了12例年龄在53至88岁之间的肛管鳞状细胞癌患者（3例男性，9例女性），他们接受了放疗-化疗联合治疗（5-氟尿嘧啶-丝裂霉素C）；肿瘤分布情况为：2例T4期，6例T3期，3例T2期，1例T1期。在11例接受评估的患者中，8例获得完全缓解，另外2例部分缓解。尽管联合治疗取得了良好效果，但仍有4例患者在9至26个月之间复发。5例患者存活，2例无疾病死亡（16至38个月），3例患者死亡，1例带瘤存活。这个小样本系列证实了这种联合治疗对体积较大肿瘤（T3-T4期）的疗效。然而，有必要在随机试验中将这些结果与单纯放疗的结果进行比较。
