Lagrange J L, Chauvel P, François E, Bourry J, Benchimol D, Bereder J M, Machiavello J C, Richelme H
Service de Radiothérapie, Centre Antoine-Lacassagne, Nice.
Ann Gastroenterol Hepatol (Paris). 1990 Mar-Apr;26(2):45-9.
From 1973 to 1987, 33 patients aged from 46 to 86 years (25 female, 8 male) were treated for a tumour of the anal canal with radiotherapy and curietherapy. Tumour distribution was 7 T1, 19 T2, 7 T3, and 4 patients were N+. After treatment it was possible to assess 31 patients; 29 were in complete remission, remission was obtained in 2 others following surgery. Tolerance was comparable to other series but 4 patients developed necrosis of the anal canal; 2 patients died under general anesthesia and 1 patient had a radiation injury of the small intestine. The sphincter was conserved in 65 p. cent of cases. Relapse occurred in 8 patients within 6-92 months, and 6 patients developed metastases. Overall survival was 78 p. cent at 3 years and 74 p. cent at 5 and 10 years. Disease-free survival was 65 p. cent at 3 and 5 years and 52 p. cent at 10 years. Our results confirm those of other series using a similar treatment plan. This treatment is difficult to put into practice. Patients must be carefully selected preferably by a team including proctologist, surgeon and radiotherapist.
1973年至1987年，对33例年龄在46岁至86岁之间的患者（25例女性，8例男性）采用放疗和镭疗治疗肛管肿瘤。肿瘤分期分布为：T1期7例，T2期19例，T3期7例，N+期4例。治疗后可对31例患者进行评估；29例完全缓解，另外2例术后缓解。耐受性与其他系列相当，但有4例患者发生肛管坏死；2例患者在全身麻醉下死亡，1例患者发生小肠放射性损伤。65%的病例保留了括约肌。8例患者在6至92个月内复发，6例发生转移。3年总生存率为78%，5年和10年为74%。无病生存率3年和5年为65%，10年为52%。我们的结果证实了其他采用类似治疗方案的系列研究结果。这种治疗方法难以实施。患者必须经过精心挑选，最好由包括直肠科医生、外科医生和放疗科医生在内的团队进行。
