Department of Pediatrics, Division of Neonatology, Sophia Children's Hospital, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Acta Paediatr. 2013 Mar;102(3):282-6. doi: 10.1111/apa.12101. Epub 2012 Dec 22.
To examine neonatal and parental predictors of executive function in very preterm (gestational age ≤30 weeks) children aged 4.0-12.0 years.
Two-hundred very preterm (mean age 8.2 ± 2.5 years) children without severe disabilities, born between 1996 and 2004, were assessed with measures of executive function including working memory, verbal fluency, planning and inhibitory control. Neonatal predictors were obtained from clinical records. Parental predictors included parental education, which was derived from questionnaires. Multiple linear regression analyses identified associations between neonatal and parental predictors and executive function in very preterm children.
Better postnatal growth at 6 weeks of corrected age-predicted better spatial span (R² = 0.03, β = 0.17, p = 0.02) and planning (R² = 0.03, β = 0.16, p = 0.04). A higher level of parental education predicted better verbal fluency (R² = 0.02, β = 0.12, p = 0.02). Verbal working memory was not predicted by neonatal risk factors or by parental education (β(s ) < 0.09, p(s ) > 0.20).
Executive function in very preterm children is associated with early postnatal growth and level of parental education but not with neonatal complications.
研究极早产儿（胎龄≤30 周）4.0-12.0 岁儿童的新生儿期和父母因素与执行功能的关系。
选择 200 名极早产儿（平均年龄 8.2±2.5 岁），无严重残疾，出生于 1996 年至 2004 年，使用执行功能测试，包括工作记忆、言语流畅性、计划和抑制控制，评估其执行功能。新生儿预测因子来自临床记录，父母预测因子包括父母教育，从问卷调查中获得。多元线性回归分析确定了极早产儿的新生儿和父母因素与执行功能之间的关联。
校正胎龄 6 周时更好的生长预测空间跨度（R²=0.03，β=0.17，p=0.02）和计划（R²=0.03，β=0.16，p=0.04）更好。较高的父母教育水平预测言语流畅性更好（R²=0.02，β=0.12，p=0.02）。言语工作记忆不受新生儿危险因素或父母教育的预测（β(s)<0.09，p(s)>0.20）。
极早产儿的执行功能与早期产后生长和父母教育水平有关，但与新生儿并发症无关。
