Ikemoto S, Kishimoto T, Iimori H, Morikawa Y, Hayahara N, Maekawa M
Department of Urology, Osaka City University Hospital, Japan.
Br J Urol. 1990 Feb;65(2):181-5. doi: 10.1111/j.1464-410x.1990.tb14695.x.
Patients with advanced malignant neoplasms have a variety of abnormal lymphocyte and monocyte functions. We examined the PHA (phytohaemagglutinin) blastogenic response of lymphocytes and interleukin-1 (IL-1) production of monocytes in 40 bladder cancer patients and 16 control subjects. The correlation between the 2 parameters was also studied. The PHA blastogenic response was measured by the incorporation of 3H-thymidine into lymphocytes. IL-1 production was assayed by the murine thymocyte 3H-thymidine incorporation assay. As a result, the PHA blastogenic response and IL-1 production were significantly lower in the high stage bladder cancer patients compared to the control subjects and low stage patients. However, there was no significant correlation between the 2 parameters. Furthermore, with the addition of indomethacin, IL-1 production in the control subjects and low stage patients improved to the same degree, but it did not reach the control level in the high stage patients.
晚期恶性肿瘤患者存在多种淋巴细胞和单核细胞功能异常。我们检测了40例膀胱癌患者和16例对照者淋巴细胞的PHA（植物血凝素）促有丝分裂反应及单核细胞白细胞介素-1（IL-1）的产生情况。还研究了这两个参数之间的相关性。通过将3H-胸腺嘧啶核苷掺入淋巴细胞来测定PHA促有丝分裂反应。通过小鼠胸腺细胞3H-胸腺嘧啶核苷掺入试验检测IL-1的产生。结果显示，与对照者和低分期患者相比，高分期膀胱癌患者的PHA促有丝分裂反应和IL-1产生显著降低。然而，这两个参数之间无显著相关性。此外，加入吲哚美辛后，对照者和低分期患者的IL-1产生有同等程度的改善，但高分期患者未达到对照水平。
