Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, China.
Respir Res. 2012 Nov 24;13(1):108. doi: 10.1186/1465-9921-13-108.
Statins are lipid-lowering agents that also exhibit pleiotropic effects in decreasing oxidative stress and inflammation. There have been several published studies reporting the use of statins in the treatment of asthma patients, but their results are not consistent. The aim of this study is to determine whether statins are beneficial for asthma administration, and explore the potential covariables that may affect their clinical effectiveness.
A systematic literature search was performed in PubMed, Embase and Cochrane Center Register of Controlled Trials from inception to September 2012. Randomized controlled trials (RCT), retrospective studies and controlled clinical trials which reported the use of statins in the treatment of asthma patients were eligible. Quality evaluation was conducted for RCT using Jadad criteria.
A total of 18 articles were included. In our study, we found no conclusive evidence to demonstrate that statins could enhance the lung function in asthmatics, although, they may reduce airway inflammation. Additionally, the results were not consistent across studies with respect to symptoms, quality of life, maintenance medication, asthma hospitalization/emergency department (ED) visits.
Statins may reduce airway inflammation in asthmatics, without having a significant effect on lung function. Further large sample and multicenter clinical trials are needed to confirm this and to see if there are more responsive phenotypes of asthma.
他汀类药物是降脂药物，具有降低氧化应激和炎症的多效作用。已有多项研究报告了他汀类药物在哮喘患者治疗中的应用，但结果并不一致。本研究旨在确定他汀类药物是否有益于哮喘治疗，并探讨可能影响其临床疗效的潜在协变量。
系统检索 PubMed、Embase 和 Cochrane 中心对照试验注册库自成立至 2012 年 9 月的文献。纳入报告他汀类药物治疗哮喘患者的随机对照试验（RCT）、回顾性研究和对照临床试验。对 RCT 采用 Jadad 标准进行质量评价。
共纳入 18 篇文章。本研究未发现确凿证据表明他汀类药物能改善哮喘患者的肺功能，但可能减轻气道炎症。此外，各项研究在症状、生活质量、维持治疗药物、哮喘住院/急诊就诊方面的结果并不一致。
他汀类药物可能减轻哮喘患者的气道炎症，但对肺功能无显著影响。需要进一步开展大样本、多中心临床试验以证实这一点，并确定是否存在更具反应性的哮喘表型。
