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他汀类药物在 COPD 和哮喘治疗中的应用——我们处于什么位置?

Statins in the treatment of COPD and asthma-where do we stand?

机构信息

Department of Thoracic Medicine and Surgery at the Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Department of Thoracic Medicine and Surgery at the Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

出版信息

Curr Opin Pharmacol. 2018 Jun;40:26-33. doi: 10.1016/j.coph.2018.01.001. Epub 2018 Jan 13.

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are the two most prevalent obstructive lung diseases that account for tremendous morbidity and mortality throughout the world. These diseases have strong inflammatory components, with multiple prior studies showing elevated levels of various inflammatory markers and cells in those with COPD and asthma. Therefore, efforts to target inflammation in management of these diseases are of great interest. Statins, which define a class of drugs that are HMG-CoA inhibitors, are used to decrease cholesterol levels and have also been described to have many pleotropic effects that include anti-inflammatory and anti-oxidative properties. These properties have led to multiple studies looking at the potential use of statins in decreasing inflammation in many diseases, including COPD and asthma. This review aims to address the current evidence behind the potential use of statins in the treatment of asthma and COPD.

摘要

哮喘和慢性阻塞性肺疾病(COPD)是世界上最常见的两种阻塞性肺部疾病,导致了巨大的发病率和死亡率。这些疾病具有强烈的炎症成分,多项先前的研究表明,COPD 和哮喘患者的各种炎症标志物和细胞水平升高。因此,人们非常关注在这些疾病的管理中靶向炎症的努力。他汀类药物是一类 HMG-CoA 抑制剂,用于降低胆固醇水平,并且还具有许多多效性作用,包括抗炎和抗氧化特性。这些特性导致了多项研究着眼于他汀类药物在降低包括 COPD 和哮喘在内的许多疾病中的炎症的潜在用途。本综述旨在探讨他汀类药物在治疗哮喘和 COPD 中的潜在用途的现有证据。

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