Theoretical Biology and Biophysics, Los Alamos National Laboratory, NM 87545, USA.
Clin Liver Dis. 2013 Feb;17(1):13-26. doi: 10.1016/j.cld.2012.09.003.
Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to extend previous models so as to understand, characterize, and compare various new HCV treatment regimens. Here we review recent modeling efforts in this direction.
丙型肝炎病毒动力学的数学建模一直是理解丙型肝炎病毒(HCV)感染动力学和估计表征 HCV 治疗效果的关键体内参数的重要工具。由于直接作用抗病毒药物的出现,需要扩展以前的模型,以便理解、描述和比较各种新的 HCV 治疗方案。在这里,我们回顾了这方面的最新建模工作。