Department of Child Health Care, Children's Hospital of Fudan University, Shanghai, China.
Department of Neonatology, International Peace Maternity & Child Hospital of the China Welfare Institute, Shanghai, China.
Ophthalmology. 2013 Mar;120(3):489-494. doi: 10.1016/j.ophtha.2012.08.025. Epub 2012 Nov 20.
To describe the development of flash visual evoked potentials (FVEPs) in preterm infants from 1 to 18 months and to determine if the maturation of FVEPs is similar to that of term infants.
Longitudinal follow-up study.
Twenty very low birth weight (VLBW) preterm infants, 42 low birth weight (LBW) preterm infants, and 41 term infants underwent FVEP recordings and neurodevelopmental examinations at 1, 3, 6, 9, 12, and 18 months of corrected and chronological ages.
The FVEP recordings were carried out with the VikingQuest-IV neuroelectrophysiological device (VikingQuest, Nicolet, WI), and neurodevelopmental assessments were made by the Development Screen Test and Bayley Scales of Infant Development, Second Edition.
At 1, 3, 6, and 9 months of age, neurodevelopment was measured with the Mental Index and Developmental Quotient. At 12 and 18 months, neurodevelopment was assessed using the Mental Developmental Index and Psychomotor Developmental Index. Two FVEP values were analyzed: the P2 amplitude (peak to peak from the preceding N2 wave) and the latency of the P2 wave.
There was no significant difference for age-dependent decreased pattern of FVEP P2 latency between preterm infants and the control group. This pattern consisted of a rapid decrease in the first 6 months of life, a gradual decline from 6 to 12 months of age, and a steady reduction from 12 to 18 months of age. The P2 latencies were prolonged significantly at all 6 recorded times in the VLBW group compared with the controls and showed a delay in the LBW group at 1 and 3 months of corrected age. The maturation of P2 latency in LBW infants is similar to that of the controls at 3 months of corrected age, but the maturation of P2 latency in VLBW children remained delayed when compared with the controls until 18 months of corrected age.
Although the FVEP development pattern of preterm infants was similar to that of healthy full-term infants, the former had deficits in visual electrophysiologic maturation, especially for VLBW children.
描述早产儿从 1 至 18 个月期间闪光视觉诱发电位（FVEP）的发育情况，并确定 FVEP 的成熟过程是否与足月婴儿相似。
纵向随访研究。
20 名极低出生体重（VLBW）早产儿、42 名低出生体重（LBW）早产儿和 41 名足月婴儿在矫正月龄和实际月龄 1、3、6、9、12 和 18 个月时接受 FVEP 记录和神经发育检查。
FVEP 记录使用 VikingQuest-IV 神经电生理设备（VikingQuest，Nicolet，WI）进行，神经发育评估采用发育筛查测试和贝利婴幼儿发育量表第二版。
在 1、3、6 和 9 个月时，使用精神指数和发育商测量神经发育。在 12 和 18 个月时，使用精神发育指数和精神运动发育指数评估神经发育。分析了两个 FVEP 值：P2 波幅（从前面的 N2 波到 P2 波的峰峰值）和 P2 波的潜伏期。
早产儿与对照组之间，FVEP P2 潜伏期随年龄下降的模式无显著差异。该模式包括在生命的前 6 个月迅速下降，从 6 个月到 12 个月逐渐下降，从 12 个月到 18 个月稳定下降。VLBW 组在所有 6 个记录时间点的 P2 潜伏期均显著延长，与对照组相比存在延迟，并在矫正月龄 1 和 3 个月时在 LBW 组显示出延迟。LBW 婴儿的 P2 潜伏期成熟过程与对照组在矫正 3 个月时相似，但 VLBW 儿童的 P2 潜伏期成熟过程与对照组相比，直到矫正 18 个月时仍存在延迟。
尽管早产儿的 FVEP 发育模式与健康的足月婴儿相似，但前者的视觉电生理成熟存在缺陷，尤其是 VLBW 儿童。
