Materials Science Centre, The University of Manchester, Manchester.
Nanomedicine. 2013 Apr;9(3):322-35. doi: 10.1016/j.nano.2012.10.008. Epub 2012 Nov 22.
Research into scaffolds tailored for specific tissue engineering and biomaterial applications continues to develop as these structures are commonly impeded by their limitations. For example, electrospun fibres and hydrogels are commonly exploited because of their ability to mimic natural tissues; however, their clinical use remains restricted due to negligible cellular infiltration and poor mechanical properties, respectively. A small number of research groups are beginning to investigate composite scaffolds based on electrospun fibres and hydrogels in an attempt to overcome their individual shortcomings. This review paper discusses the various methodologies and approaches currently undertaken to create these novel composite structures and their intended applications. The combination of these two commonly used scaffold architectures to create synergistically superior structures is showing potential with regards to therapeutic use within the tissue engineering community.
This review discusses methodologies to create novel electrospun nanofibers and hydrogels, and their intended applications. The combination of these two scaffold architectures has important future clinical applications, although their use is currently limited to the experimental tissue engineering community.
针对特定组织工程和生物材料应用而定制的支架研究仍在不断发展，因为这些结构通常受到其局限性的阻碍。例如，由于能够模仿天然组织，静电纺丝纤维和水凝胶通常被广泛利用；然而，由于细胞浸润可忽略不计和机械性能差，它们的临床应用仍然受到限制。少数研究小组开始研究基于静电纺丝纤维和水凝胶的复合支架，试图克服它们各自的缺点。本文综述了目前为创造这些新型复合结构而采用的各种方法和方法及其预期应用。将这两种常用支架结构结合起来，创造协同优越的结构，在组织工程领域的治疗应用中显示出了潜力。
本文综述了创建新型静电纺纳米纤维和水凝胶的方法及其预期应用。这两种支架结构的结合具有重要的未来临床应用，尽管它们的使用目前仅限于实验性组织工程社区。
