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药物递送中的电纺纳米纤维：控释策略的进展

Electrospun nanofibres in drug delivery: advances in controlled release strategies.

作者信息

Gaydhane Mrunalini K, Sharma Chandra Shekhar, Majumdar Saptarshi

机构信息

Creative & Advanced Research Based on Nanomaterials (CARBON) Laboratory, Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Kandi-502285 Telangana India

Poly-Nano-Bio Laboratory, Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Kandi-502285 Telangana India.

出版信息

RSC Adv. 2023 Mar 6;13(11):7312-7328. doi: 10.1039/d2ra06023j. eCollection 2023 Mar 1.

DOI:10.1039/d2ra06023j
PMID:36891485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9987416/
Abstract

Emerging drug-delivery systems demand a controlled or programmable or sustained release of drug molecules to improve therapeutic efficacy and patient compliance. Such systems have been heavily investigated as they offer safe, accurate, and quality treatment for numerous diseases. Amongst newly developed drug-delivery systems, electrospun nanofibres have emerged as promising drug excipients and are coming up as promising biomaterials. The inimitable characteristics of electrospun nanofibres in terms of their high surface-to-volume ratio, high porosity, easy drug encapsulation, and programmable release make them an astounding drug-delivery vehicle.

摘要

新兴的药物递送系统需要对药物分子进行可控、可编程或持续释放，以提高治疗效果和患者依从性。由于这些系统能为多种疾病提供安全、准确和高质量的治疗，因此受到了广泛研究。在新开发的药物递送系统中，电纺纳米纤维已成为有前景的药物赋形剂，并正成为有前景的生物材料。电纺纳米纤维具有独特的特性，如高比表面积、高孔隙率、易于药物包封和可编程释放，使其成为一种令人惊叹的药物递送载体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/9cf5b6b3d906/d2ra06023j-p3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/229a9dc0f907/d2ra06023j-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/7694607eb5fd/d2ra06023j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/34930940bf5f/d2ra06023j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/0b3f7bc847cd/d2ra06023j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/ff8114cb3e67/d2ra06023j-p1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/61ab110a1552/d2ra06023j-p2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/9cf5b6b3d906/d2ra06023j-p3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/229a9dc0f907/d2ra06023j-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/21873393b2b5/d2ra06023j-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/7694607eb5fd/d2ra06023j-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/34930940bf5f/d2ra06023j-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/0b3f7bc847cd/d2ra06023j-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/ff8114cb3e67/d2ra06023j-p1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/61ab110a1552/d2ra06023j-p2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddbb/9987416/9cf5b6b3d906/d2ra06023j-p3.jpg

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