Venkata Prathyusha E, Gomte Shyam Sudhakar, Ahmed Hafiz, Prabakaran A, Agrawal Mukta, Chella Naveen, Alexander Amit
NanoTech Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam 781101, India.
School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Hyderabad 509301, India.
Int J Biol Macromol. 2025 Jan;284(Pt 1):137834. doi: 10.1016/j.ijbiomac.2024.137834. Epub 2024 Nov 28.
Nanostructured polymer composites have gained significant attention in recent years for their remarkable potential in bone and tissue regeneration. Moreover, with the integration of 3D printing technology, these composites hold promise for use in personalized medicine, where patient-specific scaffolds can be tailored to enhance therapeutic outcomes. Therefore, this review article aims to provide a comprehensive overview of the latest advancements in the development and application of nanostructured polymeric composites within the field of tissue engineering and bone regeneration. Here, the potential of biopolymers, natural polymers, and 3D-printed polymers to craft biocompatible, non-toxic, and mechanically robust composites is discussed in brief. Further, the fabrication techniques for 3D scaffolds and various forms of nanocomposites, including nanoparticles, nanocapsules, nanofibers, nanogels, and micelles for bone and tissue regeneration, are listed. Also, particular emphasis is placed on the role of nano-scaffolds and in situ hydrogels in bone and tissue regeneration. Overall, this review provides a concise and authoritative summary of the current state-of-the-art in nanostructured polymer composites for regenerative medicine, highlighting future directions and potential clinical applications.
近年来，纳米结构聚合物复合材料因其在骨和组织再生方面的巨大潜力而备受关注。此外，随着3D打印技术的融入，这些复合材料有望用于个性化医疗，即可以定制针对患者的支架以提高治疗效果。因此，本文综述旨在全面概述纳米结构聚合物复合材料在组织工程和骨再生领域开发与应用的最新进展。在此，简要讨论了生物聚合物、天然聚合物和3D打印聚合物用于制造生物相容性、无毒且机械性能强大的复合材料的潜力。此外，列出了用于骨和组织再生的3D支架及各种形式纳米复合材料（包括纳米颗粒、纳米胶囊、纳米纤维、纳米凝胶和胶束）的制造技术。同时，特别强调了纳米支架和原位水凝胶在骨和组织再生中的作用。总体而言，本综述对用于再生医学的纳米结构聚合物复合材料的当前技术水平提供了简洁而权威的总结，突出了未来方向和潜在的临床应用。
