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从苦菜根部分离鉴定酚类化合物及其抗氧化活性。

Isolation and identification of the phenolic compounds from the roots of Sanguisorba officinalis L. and their antioxidant activities.

机构信息

School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.

出版信息

Molecules. 2012 Nov 23;17(12):13917-22. doi: 10.3390/molecules171213917.

Abstract

Four phenolic compounds were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the basis of chemical and spectroscopic methods, their structures were identified as methyl 4-O-β-D-glucopyranosy-5-hydroxy-3-methoxylbenzoate (1), 3,3′,4′-tri-O-methylellagic acid (2), fisetinidol-(4α-8)-catechin (3), and (+)-catechin (4). Compound 1 is a new phenolic glycoside and compounds 2 and 3 were isolated from the Sanguisorba genus for the first time. Compounds 1–4 were also assayed for their antioxidant activities using the DPPH free radical assay.

摘要

从地榆根中通过硅胶柱色谱和制备高效液相色谱分离得到了 4 种酚类化合物。根据化学和光谱方法,鉴定了它们的结构为:甲基 4-O-β-D-吡喃葡萄糖基-5-羟基-3-甲氧基苯甲酸酯(1)、3,3′,4′-三-O-甲基鞣花酸(2)、非瑟酮基-(4α-8)-儿茶素(3)和(+)-儿茶素(4)。化合物 1 是一种新的酚糖苷,化合物 2 和 3 是首次从地榆属植物中分离得到的。还采用 DPPH 自由基法测定了化合物 1-4 的抗氧化活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19a1/6268844/bbdc285c3a44/molecules-17-13917-g001.jpg

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