Dedert Eric A, Harper Leia A, Calhoun Patrick S, Dennis Michelle F, Beckham Jean C
Durham Veterans Affairs Medical Center, 508 Fulton St. (116 B), Durham, NC 27705, USA.
J Clin Psychol Med Settings. 2013 Mar;20(1):46-55. doi: 10.1007/s10880-012-9305-4.
The literature on PTSD and metabolic disease risk factors has been limited by lacking investigation of the potential influence of commonly comorbid disorders and the role of race. In this study data were provided by a sample of 134 women (63 PTSD and 71 without PTSD). Separate sets of models examining associations of psychiatric disorder classifications with metabolic disease risk factors were used. Each model included race (African American or Caucasian), psychiatric disorder, and their interaction. There was an interaction of race and PTSD on body mass index, abdominal obesity, and triglycerides. While PTSD was not generally associated with deleterious health effects in African American participants, PTSD was related to worse metabolic disease risk factors in Caucasians. MDD was associated with metabolic disease risk factors, but there were no interactions with race. Results support the importance of race in the relationship between PTSD and metabolic disease risk factors. Future research would benefit from analysis of cultural factors to explain how race might influence metabolic disease risk factors in PTSD.
关于创伤后应激障碍（PTSD）与代谢疾病风险因素的文献，因缺乏对常见共病障碍的潜在影响以及种族作用的研究而受到限制。在本研究中，数据来自134名女性样本（63名患有PTSD，71名未患PTSD）。使用了单独的模型集来检验精神障碍分类与代谢疾病风险因素之间的关联。每个模型都包括种族（非裔美国人或白种人）、精神障碍及其相互作用。种族和PTSD在体重指数、腹部肥胖和甘油三酯方面存在相互作用。虽然PTSD在非裔美国参与者中通常与有害健康影响无关，但在白种人中，PTSD与更差的代谢疾病风险因素有关。重度抑郁症（MDD）与代谢疾病风险因素有关，但与种族没有相互作用。结果支持了种族在PTSD与代谢疾病风险因素关系中的重要性。未来的研究将受益于对文化因素的分析，以解释种族如何影响PTSD中的代谢疾病风险因素。
