创伤后应激障碍、心血管和代谢疾病：证据综述。
Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence.
机构信息
VA Research Service, Department of Psychiatry and Behavioral Sciences, Durham Veterans Affairs and Duke University Medical Centers, Durham, NC, USA.
出版信息
Ann Behav Med. 2010 Feb;39(1):61-78. doi: 10.1007/s12160-010-9165-9.
Abstract
BACKGROUND
Posttraumatic stress disorder (PTSD) is a significant risk factor for cardiovascular and metabolic disease.
PURPOSE
The purpose of the current review is to evaluate the evidence suggesting that PTSD increases cardiovascular and metabolic risk factors, and to identify possible biomarkers and psychosocial characteristics and behavioral variables that are associated with these outcomes.
METHODS
A systematic literature search in the period of 2002-2009 for PTSD, cardiovascular disease, and metabolic disease was conducted.
RESULTS
The literature search yielded 78 studies on PTSD and cardiovascular/metabolic disease and biomarkers.
CONCLUSIONS
Although the available literature suggests an association of PTSD with cardiovascular disease and biomarkers, further research must consider potential confounds, incorporate longitudinal designs, and conduct careful PTSD assessments in diverse samples to address gaps in the research literature. Research on metabolic disease and biomarkers suggests an association with PTSD, but has not progressed as far as the cardiovascular research.
摘要
背景
创伤后应激障碍（PTSD）是心血管和代谢疾病的重要危险因素。
目的
本综述旨在评估 PTSD 增加心血管和代谢风险因素的证据，并确定与这些结果相关的可能生物标志物以及心理社会特征和行为变量。
方法
对 2002-2009 年 PTSD、心血管疾病和代谢疾病的文献进行了系统检索。
结果
文献检索得到了 78 项关于 PTSD 和心血管/代谢疾病及生物标志物的研究。
结论
尽管现有文献表明 PTSD 与心血管疾病和生物标志物有关，但进一步的研究必须考虑潜在的混杂因素，采用纵向设计，并在不同样本中进行仔细的 PTSD 评估，以解决研究文献中的空白。关于代谢疾病和生物标志物的研究表明与 PTSD 有关，但进展不如心血管研究那么深入。
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