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主动脉内球囊反搏在急性心肌梗死合并心源性休克患者中的应用:ALKK-PCI 注册研究结果。

Intra-aortic balloon pump in patients with acute myocardial infarction complicated by cardiogenic shock: results of the ALKK-PCI registry.

机构信息

Klinikum Ludwigshafen, Medizinische Klinik B, Ludwigshafen, Germany.

出版信息

Clin Res Cardiol. 2013 Mar;102(3):223-7. doi: 10.1007/s00392-012-0523-4. Epub 2012 Nov 21.

Abstract

AIMS

The recommendation for the use of the intra-aortic balloon pump (IABP) as adjunct in patients with cardiogenic shock undergoing primary PCI in current guidelines is controversial. We sought to investigate the use and impact of the outcome of IABP in current practice of percutaneous coronary interventions in Germany.

METHODS AND RESULTS

Between January 2006 and December 2011, a total of 55,008 consecutive patients with acute coronary syndromes undergoing PCI in 41 hospitals were enrolled into the prospective Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte registry. Of these, 22,039 had STEMI and 32,969 had NSTEMI, and cardiogenic shock was observed in 1,435 (6.5 %) and 478 (1.4 %), respectively. Of the total of 1,913 patients with shock, 487 (25.5 %) were treated with IABP. In-hospital mortality with and without IABP was 43.5 and 37.4 %. In the multivariate analysis, the use of IABP was associated with a strong trend for an increased mortality (odds ratio 1.45, 95 % CI 1.15-1.84).

CONCLUSION

In the current clinical practice in Germany, IABP is used only in one quarter of patients with cardiogenic shock treated with primary PCI. We observed no benefit of IABP on outcome, which supports the findings of the randomized IABP-Shock II trial.

摘要

目的

当前指南中建议将主动脉内球囊泵(IABP)作为心原性休克患者行直接经皮冠状动脉介入治疗(PCI)的辅助治疗手段,但这一推荐存在争议。本研究旨在探讨德国目前经皮冠状动脉介入治疗实践中 IABP 的使用情况及其对结果的影响。

方法和结果

2006 年 1 月至 2011 年 12 月,共有 41 家医院的 55008 例急性冠状动脉综合征患者连续接受了 PCI,其中 22039 例患者为 ST 段抬高型心肌梗死,32969 例为非 ST 段抬高型心肌梗死,心原性休克分别发生于 1435 例(6.5%)和 478 例(1.4%)患者中。在总共 1913 例休克患者中,487 例(25.5%)接受了 IABP 治疗。使用 IABP 和未使用 IABP 的院内死亡率分别为 43.5%和 37.4%。多变量分析显示,使用 IABP 与死亡率升高呈强相关(比值比 1.45,95%置信区间 1.15-1.84)。

结论

在德国目前的临床实践中,IABP 仅用于四分之一接受直接 PCI 治疗的心原性休克患者。我们观察到 IABP 并未改善患者预后,这与随机 IABP-Shock II 试验的结果一致。

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